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Integrated Transcriptomic and Metabolomic Mapping Reveals the Mechanism of Action of Ceftazidime/Avibactam against Pan-Drug-Resistant Klebsiella pneumoniae.
Hussein M, Allobawi R, Zhao J, Yu H, Neville SL, Wilksch J, Wong LJM, Baker M, McDevitt CA, Rao GG, Li J, Velkov T. Hussein M, et al. Among authors: allobawi r. ACS Infect Dis. 2023 Dec 8;9(12):2409-2422. doi: 10.1021/acsinfecdis.3c00264. Epub 2023 Oct 25. ACS Infect Dis. 2023. PMID: 37878861 Free PMC article.
Effective Strategy Targeting Polymyxin-Resistant Gram-Negative Pathogens: Polymyxin B in Combination with the Selective Serotonin Reuptake Inhibitor Sertraline.
Hussein M, Schneider-Futschik EK, Paulin OKA, Allobawi R, Crawford S, Zhou QT, Hanif A, Baker M, Zhu Y, Li J, Velkov T. Hussein M, et al. Among authors: allobawi r. ACS Infect Dis. 2020 Jun 12;6(6):1436-1450. doi: 10.1021/acsinfecdis.0c00108. Epub 2020 May 25. ACS Infect Dis. 2020. PMID: 32427476
Unique mechanistic insights into pathways associated with the synergistic activity of polymyxin B and caspofungin against multidrug-resistant Klebsiella pneumoniae.
Hussein M, Wong LJM, Zhao J, Rees VE, Allobawi R, Sharma R, Rao GG, Baker M, Li J, Velkov T. Hussein M, et al. Among authors: allobawi r. Comput Struct Biotechnol J. 2022 Feb 25;20:1077-1087. doi: 10.1016/j.csbj.2022.02.021. eCollection 2022. Comput Struct Biotechnol J. 2022. PMID: 35284046 Free PMC article.
Untargeted metabolomics to evaluate polymyxin B toxicodynamics following direct intracerebroventricular administration into the rat brain.
Hussein M, Oberrauch S, Allobawi R, Cornthwaite-Duncan L, Lu J, Sharma R, Baker M, Li J, Rao GG, Velkov T. Hussein M, et al. Among authors: allobawi r. Comput Struct Biotechnol J. 2022 Nov 7;20:6067-6077. doi: 10.1016/j.csbj.2022.10.041. eCollection 2022. Comput Struct Biotechnol J. 2022. PMID: 36420146 Free PMC article.