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Integrated Transcriptomic and Metabolomic Mapping Reveals the Mechanism of Action of Ceftazidime/Avibactam against Pan-Drug-Resistant Klebsiella pneumoniae.
Hussein M, Allobawi R, Zhao J, Yu H, Neville SL, Wilksch J, Wong LJM, Baker M, McDevitt CA, Rao GG, Li J, Velkov T. Hussein M, et al. Among authors: yu h. ACS Infect Dis. 2023 Dec 8;9(12):2409-2422. doi: 10.1021/acsinfecdis.3c00264. Epub 2023 Oct 25. ACS Infect Dis. 2023. PMID: 37878861 Free PMC article.
The combination of colistin and doripenem is synergistic against Klebsiella pneumoniae at multiple inocula and suppresses colistin resistance in an in vitro pharmacokinetic/pharmacodynamic model.
Deris ZZ, Yu HH, Davis K, Soon RL, Jacob J, Ku CK, Poudyal A, Bergen PJ, Tsuji BT, Bulitta JB, Forrest A, Paterson DL, Velkov T, Li J, Nation RL. Deris ZZ, et al. Among authors: yu hh. Antimicrob Agents Chemother. 2012 Oct;56(10):5103-12. doi: 10.1128/AAC.01064-12. Epub 2012 Jul 16. Antimicrob Agents Chemother. 2012. PMID: 22802247 Free PMC article.
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