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Intrathecal delivery of nanoparticle PARP inhibitor to the cerebrospinal fluid for the treatment of metastatic medulloblastoma.
Khang M, Lee JH, Lee T, Suh HW, Lee S, Cavaliere A, Rushing A, Geraldo LH, Belitzky E, Rossano S, de Feyter HM, Shin K, Huttner A, Roussel MF, Thomas JL, Carson RE, Marquez-Nostra B, Bindra RS, Saltzman WM. Khang M, et al. Among authors: de feyter hm. Sci Transl Med. 2023 Nov;15(720):eadi1617. doi: 10.1126/scitranslmed.adi1617. Epub 2023 Nov 1. Sci Transl Med. 2023. PMID: 37910601 Free PMC article.
Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination.
Martirosian V, Deshpande K, Zhou H, Shen K, Smith K, Northcott P, Lin M, Stepanosyan V, Das D, Remsik J, Isakov D, Boire A, De Feyter H, Hurth K, Li S, Wiemels J, Nakamura B, Shao L, Danilov C, Chen T, Neman J. Martirosian V, et al. Cell Rep. 2021 Jul 27;36(4):109475. doi: 10.1016/j.celrep.2021.109475. Cell Rep. 2021. PMID: 34320362 Free article. No abstract available.
Glutamate metabolism in major depressive disorder.
Abdallah CG, Jiang L, De Feyter HM, Fasula M, Krystal JH, Rothman DL, Mason GF, Sanacora G. Abdallah CG, et al. Among authors: de feyter hm. Am J Psychiatry. 2014 Dec 1;171(12):1320-7. doi: 10.1176/appi.ajp.2014.14010067. Epub 2014 Oct 31. Am J Psychiatry. 2014. PMID: 25073688 Free PMC article.
2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity.
Sulkowski PL, Corso CD, Robinson ND, Scanlon SE, Purshouse KR, Bai H, Liu Y, Sundaram RK, Hegan DC, Fons NR, Breuer GA, Song Y, Mishra-Gorur K, De Feyter HM, de Graaf RA, Surovtseva YV, Kachman M, Halene S, Günel M, Glazer PM, Bindra RS. Sulkowski PL, et al. Among authors: de feyter hm, de graaf ra. Sci Transl Med. 2017 Feb 1;9(375):eaal2463. doi: 10.1126/scitranslmed.aal2463. Sci Transl Med. 2017. PMID: 28148839 Free PMC article.
Preclinical evaluation of a brain penetrant PARP PET imaging probe in rat glioblastoma and nonhuman primates.
Chen B, Ojha DP, Toyonaga T, Tong J, Pracitto R, Thomas MA, Liu M, Kapinos M, Zhang L, Zheng MQ, Holden D, Fowles K, Ropchan J, Nabulsi N, De Feyter H, Carson RE, Huang Y, Cai Z. Chen B, et al. Eur J Nucl Med Mol Imaging. 2023 Jun;50(7):2081-2099. doi: 10.1007/s00259-023-06162-y. Epub 2023 Feb 28. Eur J Nucl Med Mol Imaging. 2023. PMID: 36849748
Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination.
Martirosian V, Deshpande K, Zhou H, Shen K, Smith K, Northcott P, Lin M, Stepanosyan V, Das D, Remsik J, Isakov D, Boire A, De Feyter H, Hurth K, Li S, Wiemels J, Nakamura B, Shao L, Danilov C, Chen T, Neman J. Martirosian V, et al. Cell Rep. 2021 Jun 29;35(13):109302. doi: 10.1016/j.celrep.2021.109302. Cell Rep. 2021. PMID: 34192534 Free PMC article.
Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo.
De Feyter HM, Behar KL, Corbin ZA, Fulbright RK, Brown PB, McIntyre S, Nixon TW, Rothman DL, de Graaf RA. De Feyter HM, et al. Among authors: de graaf ra. Sci Adv. 2018 Aug 22;4(8):eaat7314. doi: 10.1126/sciadv.aat7314. eCollection 2018 Aug. Sci Adv. 2018. PMID: 30140744 Free PMC article.
52 results