Clark RJ - Search Results

1

Computational Design of α-Conotoxins to Target Specific Nicotinic Acetylcholine Receptor Subtypes.

Wu X, Hone AJ, Huang YH, Clark RJ, McIntosh JM, Kaas Q, Craik DJ. Wu X, et al. Among authors: clark rj. Chemistry. 2024 Feb 1;30(7):e202302909. doi: 10.1002/chem.202302909. Epub 2023 Dec 18. Chemistry. 2024. PMID: 37910861

2

Disulfide folding pathways of cystine knot proteins. Tying the knot within the circular backbone of the cyclotides.

Daly NL, Clark RJ, Craik DJ. Daly NL, et al. Among authors: clark rj. J Biol Chem. 2003 Feb 21;278(8):6314-22. doi: 10.1074/jbc.M210492200. Epub 2002 Dec 12. J Biol Chem. 2003. PMID: 12482862 Free article.

3

Linearization of a naturally occurring circular protein maintains structure but eliminates hemolytic activity.

Barry DG, Daly NL, Clark RJ, Sando L, Craik DJ. Barry DG, et al. Among authors: clark rj. Biochemistry. 2003 Jun 10;42(22):6688-95. doi: 10.1021/bi027323n. Biochemistry. 2003. PMID: 12779323

4

Microcin J25 has a threaded sidechain-to-backbone ring structure and not a head-to-tail cyclized backbone.

Rosengren KJ, Clark RJ, Daly NL, Göransson U, Jones A, Craik DJ. Rosengren KJ, et al. Among authors: clark rj. J Am Chem Soc. 2003 Oct 15;125(41):12464-74. doi: 10.1021/ja0367703. J Am Chem Soc. 2003. PMID: 14531690

5

Conserved structural and sequence elements implicated in the processing of gene-encoded circular proteins.

Dutton JL, Renda RF, Waine C, Clark RJ, Daly NL, Jennings CV, Anderson MA, Craik DJ. Dutton JL, et al. Among authors: clark rj. J Biol Chem. 2004 Nov 5;279(45):46858-67. doi: 10.1074/jbc.M407421200. Epub 2004 Aug 24. J Biol Chem. 2004. PMID: 15328347 Free article.

6

Disulfide bond mutagenesis and the structure and function of the head-to-tail macrocyclic trypsin inhibitor SFTI-1.

Korsinczky ML, Clark RJ, Craik DJ. Korsinczky ML, et al. Among authors: clark rj. Biochemistry. 2005 Feb 1;44(4):1145-53. doi: 10.1021/bi048297r. Biochemistry. 2005. PMID: 15667208

7

Engineering stable peptide toxins by means of backbone cyclization: stabilization of the alpha-conotoxin MII.

Clark RJ, Fischer H, Dempster L, Daly NL, Rosengren KJ, Nevin ST, Meunier FA, Adams DJ, Craik DJ. Clark RJ, et al. Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13767-72. doi: 10.1073/pnas.0504613102. Epub 2005 Sep 14. Proc Natl Acad Sci U S A. 2005. PMID: 16162671 Free PMC article.

8

Kalata B8, a novel antiviral circular protein, exhibits conformational flexibility in the cystine knot motif.

Daly NL, Clark RJ, Plan MR, Craik DJ. Daly NL, et al. Among authors: clark rj. Biochem J. 2006 Feb 1;393(Pt 3):619-26. doi: 10.1042/BJ20051371. Biochem J. 2006. PMID: 16207177 Free PMC article.

9

Structural plasticity of the cyclic-cystine-knot framework: implications for biological activity and drug design.

Clark RJ, Daly NL, Craik DJ. Clark RJ, et al. Biochem J. 2006 Feb 15;394(Pt 1):85-93. doi: 10.1042/BJ20051691. Biochem J. 2006. PMID: 16300479 Free PMC article.

10

The synthesis, structural characterization, and receptor specificity of the alpha-conotoxin Vc1.1.

Clark RJ, Fischer H, Nevin ST, Adams DJ, Craik DJ. Clark RJ, et al. J Biol Chem. 2006 Aug 11;281(32):23254-63. doi: 10.1074/jbc.M604550200. Epub 2006 Jun 5. J Biol Chem. 2006. PMID: 16754662 Free article.

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