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Effects of aluminum-salt, CpG and emulsion adjuvants on the stability and immunogenicity of a virus-like particle displaying the SARS-CoV-2 receptor-binding domain (RBD).
Kumru OS, Bajoria S, Kaur K, Hickey JM, Van Slyke G, Doering J, Berman K, Richardson C, Lien H, Kleanthous H, Mantis NJ, Joshi SB, Volkin DB. Kumru OS, et al. Among authors: kaur k. Hum Vaccin Immunother. 2023 Aug;19(2):2264594. doi: 10.1080/21645515.2023.2264594. Epub 2023 Nov 6. Hum Vaccin Immunother. 2023. PMID: 37932241 Free PMC article.
Antigen-adjuvant interactions, stability, and immunogenicity profiles of a SARS-CoV-2 receptor-binding domain (RBD) antigen formulated with aluminum salt and CpG adjuvants.
Bajoria S, Kaur K, Kumru OS, Van Slyke G, Doering J, Novak H, Rodriguez Aponte SA, Dalvie NC, Naranjo CA, Johnston RS, Silverman JM, Kleanthous H, Love JC, Mantis NJ, Joshi SB, Volkin DB. Bajoria S, et al. Among authors: kaur k. Hum Vaccin Immunother. 2022 Nov 30;18(5):2079346. doi: 10.1080/21645515.2022.2079346. Epub 2022 Jun 6. Hum Vaccin Immunother. 2022. PMID: 35666264 Free PMC article.
Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice.
Dalvie NC, Rodriguez-Aponte SA, Hartwell BL, Tostanoski LH, Biedermann AM, Crowell LE, Kaur K, Kumru OS, Carter L, Yu J, Chang A, McMahan K, Courant T, Lebas C, Lemnios AA, Rodrigues KA, Silva M, Johnston RS, Naranjo CA, Tracey MK, Brady JR, Whittaker CA, Yun D, Brunette N, Wang JY, Walkey C, Fiala B, Kar S, Porto M, Lok M, Andersen H, Lewis MG, Love KR, Camp DL, Silverman JM, Kleanthous H, Joshi SB, Volkin DB, Dubois PM, Collin N, King NP, Barouch DH, Irvine DJ, Love JC. Dalvie NC, et al. Among authors: kaur k. Proc Natl Acad Sci U S A. 2021 Sep 21;118(38):e2106845118. doi: 10.1073/pnas.2106845118. Proc Natl Acad Sci U S A. 2021. PMID: 34493582 Free PMC article.
SARS-CoV-2 receptor binding domain displayed on HBsAg virus-like particles elicits protective immunity in macaques.
Dalvie NC, Tostanoski LH, Rodriguez-Aponte SA, Kaur K, Bajoria S, Kumru OS, Martinot AJ, Chandrashekar A, McMahan K, Mercado NB, Yu J, Chang A, Giffin VM, Nampanya F, Patel S, Bowman L, Naranjo CA, Yun D, Flinchbaugh Z, Pessaint L, Brown R, Velasco J, Teow E, Cook A, Andersen H, Lewis MG, Camp DL, Silverman JM, Nagar GS, Rao HD, Lothe RR, Chandrasekharan R, Rajurkar MP, Shaligram US, Kleanthous H, Joshi SB, Volkin DB, Biswas S, Love JC, Barouch DH. Dalvie NC, et al. Among authors: kaur k. Sci Adv. 2022 Mar 18;8(11):eabl6015. doi: 10.1126/sciadv.abl6015. Epub 2022 Mar 16. Sci Adv. 2022. PMID: 35294244 Free PMC article.
Molecular engineering of a cryptic epitope in Spike RBD improves manufacturability and neutralizing breadth against SARS-CoV-2 variants.
Rodriguez-Aponte SA, Dalvie NC, Wong TY, Johnston RS, Naranjo CA, Bajoria S, Kumru OS, Kaur K, Russ BP, Lee KS, Cyphert HA, Barbier M, Rao HD, Rajurkar MP, Lothe RR, Shaligram US, Batwal S, Chandrasekaran R, Nagar G, Kleanthous H, Biswas S, Bevere JR, Joshi SB, Volkin DB, Damron FH, Love JC. Rodriguez-Aponte SA, et al. Among authors: kaur k. Vaccine. 2023 Jan 27;41(5):1108-1118. doi: 10.1016/j.vaccine.2022.12.062. Epub 2022 Dec 29. Vaccine. 2023. PMID: 36610932 Free PMC article.
Holistic process development to mitigate proteolysis of a subunit rotavirus vaccine candidate produced in Pichia pastoris by means of an acid pH pulse during fed-batch fermentation.
Velez-Suberbie ML, Morris SA, Kaur K, Hickey JM, Joshi SB, Volkin DB, Bracewell DG, Mukhopadhyay TK. Velez-Suberbie ML, et al. Among authors: kaur k. Biotechnol Prog. 2020 May;36(3):e2966. doi: 10.1002/btpr.2966. Epub 2020 Feb 3. Biotechnol Prog. 2020. PMID: 31960616 Free PMC article.
Mechanism of Thimerosal-Induced Structural Destabilization of a Recombinant Rotavirus P[4] Protein Antigen Formulated as a Multi-Dose Vaccine.
Kaur K, Xiong J, Sawant N, Agarwal S, Hickey JM, Holland DA, Mukhopadhyay TK, Brady JR, Dalvie NC, Tracey MK, Love KR, Love JC, Weis DD, Joshi SB, Volkin DB. Kaur K, et al. J Pharm Sci. 2021 Mar;110(3):1054-1066. doi: 10.1016/j.xphs.2020.11.033. Epub 2020 Dec 3. J Pharm Sci. 2021. PMID: 33278412 Free PMC article.
Rapid Developability Assessments to Formulate Recombinant Protein Antigens as Stable, Low-Cost, Multi-Dose Vaccine Candidates: Case-Study With Non-Replicating Rotavirus (NRRV) Vaccine Antigens.
Sawant N, Kaur K, Holland DA, Hickey JM, Agarwal S, Brady JR, Dalvie NC, Tracey MK, Velez-Suberbie ML, Morris SA, Jacob SI, Bracewell DG, Mukhopadhyay TK, Love KR, Love JC, Joshi SB, Volkin DB. Sawant N, et al. Among authors: kaur k. J Pharm Sci. 2021 Mar;110(3):1042-1053. doi: 10.1016/j.xphs.2020.11.039. Epub 2020 Dec 5. J Pharm Sci. 2021. PMID: 33285182 Free PMC article.
Crystallization of a nonreplicating rotavirus vaccine candidate.
Hong MS, Kaur K, Sawant N, Joshi SB, Volkin DB, Braatz RD. Hong MS, et al. Among authors: kaur k. Biotechnol Bioeng. 2021 Apr;118(4):1750-1756. doi: 10.1002/bit.27699. Epub 2021 Feb 19. Biotechnol Bioeng. 2021. PMID: 33527346 Free PMC article.
Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus.
Dalvie NC, Brady JR, Crowell LE, Tracey MK, Biedermann AM, Kaur K, Hickey JM, Kristensen DL 2nd, Bonnyman AD, Rodriguez-Aponte SA, Whittaker CA, Bok M, Vega C, Mukhopadhyay TK, Joshi SB, Volkin DB, Parreño V, Love KR, Love JC. Dalvie NC, et al. Among authors: kaur k. Microb Cell Fact. 2021 May 1;20(1):94. doi: 10.1186/s12934-021-01583-6. Microb Cell Fact. 2021. PMID: 33933073 Free PMC article.
1,664 results