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Page 1
Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal.
Maji A, Soutar CP, Zhang J, Lewandowska A, Uno BE, Yan S, Shelke Y, Murhade G, Nimerovsky E, Borcik CG, Arango AS, Lange JD, Marin-Toledo JP, Lyu Y, Bailey KL, Roady PJ, Holler JT, Khandelwal A, SantaMaria AM, Sanchez H, Juvvadi PR, Johns G, Hageman MJ, Krise J, Gebremariam T, Youssef EG, Bartizal K, Marr KA, Steinbach WJ, Ibrahim AS, Patterson TF, Wiederhold NP, Andes DR, Pogorelov TV, Schwieters CD, Fan TM, Rienstra CM, Burke MD. Maji A, et al. Among authors: uno be. Nature. 2023 Nov;623(7989):1079-1085. doi: 10.1038/s41586-023-06710-4. Epub 2023 Nov 8. Nature. 2023. PMID: 37938782 Free PMC article.
Electronic tuning of site-selectivity.
Wilcock BC, Uno BE, Bromann GL, Clark MJ, Anderson TM, Burke MD. Wilcock BC, et al. Among authors: uno be. Nat Chem. 2012 Dec;4(12):996-1003. doi: 10.1038/nchem.1495. Nat Chem. 2012. PMID: 23174979 Free PMC article.
Amphotericin forms an extramembranous and fungicidal sterol sponge.
Anderson TM, Clay MC, Cioffi AG, Diaz KA, Hisao GS, Tuttle MD, Nieuwkoop AJ, Comellas G, Maryum N, Wang S, Uno BE, Wildeman EL, Gonen T, Rienstra CM, Burke MD. Anderson TM, et al. Among authors: uno be. Nat Chem Biol. 2014 May;10(5):400-6. doi: 10.1038/nchembio.1496. Epub 2014 Mar 30. Nat Chem Biol. 2014. PMID: 24681535 Free PMC article.
Amphotericin primarily kills yeast by simply binding ergosterol.
Gray KC, Palacios DS, Dailey I, Endo MM, Uno BE, Wilcock BC, Burke MD. Gray KC, et al. Among authors: uno be. Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2234-9. doi: 10.1073/pnas.1117280109. Epub 2012 Jan 17. Proc Natl Acad Sci U S A. 2012. PMID: 22308411 Free PMC article.