Arkin MR - Search Results

1

The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.

Braxton JR, Altobelli CR, Tucker MR, Tse E, Thwin AC, Arkin MR, Southworth DR. Braxton JR, et al. Among authors: arkin mr. Nat Struct Mol Biol. 2023 Dec;30(12):2009-2019. doi: 10.1038/s41594-023-01126-0. Epub 2023 Nov 9. Nat Struct Mol Biol. 2023. PMID: 37945741 Free PMC article.

2

Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.

Mott BT, Ferreira RS, Simeonov A, Jadhav A, Ang KK, Leister W, Shen M, Silveira JT, Doyle PS, Arkin MR, McKerrow JH, Inglese J, Austin CP, Thomas CJ, Shoichet BK, Maloney DJ. Mott BT, et al. Among authors: arkin mr. J Med Chem. 2010 Jan 14;53(1):52-60. doi: 10.1021/jm901069a. J Med Chem. 2010. PMID: 19908842 Free PMC article.

3

Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists.

Zhong M, Shen W, Barr KJ, Arbitrario JP, Arkin MR, Bui M, Chen T, Cunningham BC, Evanchik MJ, Hanan EJ, Hoch U, Huen K, Hyde J, Kumer JL, Lac T, Lawrence CE, Martell JR, Oslob JD, Paulvannan K, Prabhu S, Silverman JA, Wright J, Yu CH, Zhu J, Flanagan WM. Zhong M, et al. Among authors: arkin mr. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5269-73. doi: 10.1016/j.bmcl.2010.06.145. Epub 2010 Jul 23. Bioorg Med Chem Lett. 2010. PMID: 20655213

4

A threonine turnstile defines a dynamic amphiphilic binding motif in the AAA ATPase p97 allosteric binding site.

Burnett JC, Lim C, Peyser BD, Samankumara LP, Kovaliov M, Colombo R, Bulfer SL, LaPorte MG, Hermone AR, McGrath CF, Arkin MR, Gussio R, Huryn DM, Wipf P. Burnett JC, et al. Among authors: arkin mr. Org Biomol Chem. 2017 May 16;15(19):4096-4114. doi: 10.1039/c7ob00526a. Org Biomol Chem. 2017. PMID: 28352916 Free PMC article.

5

Autophagy Receptor-Inspired Antibody-Fusion Proteins for Targeted Intracellular Degradation.

Jiang Z, Kuo YH, Arkin MR. Jiang Z, et al. Among authors: arkin mr. J Am Chem Soc. 2023 Nov 8;145(44):23939-23947. doi: 10.1021/jacs.3c05199. Epub 2023 Sep 25. J Am Chem Soc. 2023. PMID: 37748140 Free PMC article.

6

Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II.

Hawtin RE, Stockett DE, Byl JA, McDowell RS, Nguyen T, Arkin MR, Conroy A, Yang W, Osheroff N, Fox JA. Hawtin RE, et al. Among authors: arkin mr. PLoS One. 2010 Apr 15;5(4):e10186. doi: 10.1371/journal.pone.0010186. PLoS One. 2010. PMID: 20419121 Free PMC article.

7

Discovery and characterization of cooperative ligand binding in the adaptive region of interleukin-2.

Hyde J, Braisted AC, Randal M, Arkin MR. Hyde J, et al. Among authors: arkin mr. Biochemistry. 2003 Jun 3;42(21):6475-83. doi: 10.1021/bi034138g. Biochemistry. 2003. PMID: 12767230

8

Probing structural adaptivity at PPI interfaces with small molecules.

Wilson CG, Arkin MR. Wilson CG, et al. Among authors: arkin mr. Drug Discov Today Technol. 2013 Dec;10(4):e501-8. doi: 10.1016/j.ddtec.2012.10.009. Drug Discov Today Technol. 2013. PMID: 24451641 Review.

9

Bringing together the academic drug discovery community.

Slusher BS, Conn PJ, Frye S, Glicksman M, Arkin M. Slusher BS, et al. Nat Rev Drug Discov. 2013 Nov;12(11):811-2. doi: 10.1038/nrd4155. Nat Rev Drug Discov. 2013. PMID: 24172316 Free PMC article.

10

Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6.

Heise CE, Murray J, Augustyn KE, Bravo B, Chugha P, Cohen F, Giannetti AM, Gibbons P, Hannoush RN, Hearn BR, Jaishankar P, Ly CQ, Shah K, Stanger K, Steffek M, Tang Y, Zhao X, Lewcock JW, Renslo AR, Flygare J, Arkin MR. Heise CE, et al. Among authors: arkin mr. PLoS One. 2012;7(12):e50864. doi: 10.1371/journal.pone.0050864. Epub 2012 Dec 5. PLoS One. 2012. PMID: 23227217 Free PMC article.

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