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Estrogen receptor 1 chromatin profiling in human breast tumors reveals high inter-patient heterogeneity with enrichment of risk SNPs and enhancer activity at most-conserved regions.
Joosten SEP, Gregoricchio S, Stelloo S, Yapıcı E, Huang CF, Yavuz K, Donaldson Collier M, Morova T, Altintaş UB, Kim Y, Canisius S, Moelans CB, van Diest PJ, Korkmaz G, Lack NA, Vermeulen M, Linn SC, Zwart W. Joosten SEP, et al. Among authors: morova t. Genome Res. 2024 May 15;34(4):539-555. doi: 10.1101/gr.278680.123. Genome Res. 2024. PMID: 38719469 Free PMC article.
Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.
Ozyerli-Goknar E, Kala EY, Aksu AC, Bulut I, Cingöz A, Nizamuddin S, Biniossek M, Seker-Polat F, Morova T, Aztekin C, Kung SHY, Syed H, Tuncbag N, Gönen M, Philpott M, Cribbs AP, Acilan C, Lack NA, Onder TT, Timmers HTM, Bagci-Onder T. Ozyerli-Goknar E, et al. Among authors: morova t. Cell Commun Signal. 2023 Nov 16;21(1):328. doi: 10.1186/s12964-023-01335-6. Cell Commun Signal. 2023. PMID: 37974198 Free PMC article.
Breast cancer risk SNPs converge on estrogen receptor binding sites commonly shared between breast tumors to locally alter estrogen signalling output.
Joosten SE, Gregoricchio S, Stelloo S, Yapıcı E, Huang CF, Collier MD, Morova T, Altintas B, Kim Y, Canisius S, Korkmaz G, Lack N, Vermeulen M, Linn SC, Zwart W. Joosten SE, et al. Among authors: morova t. bioRxiv [Preprint]. 2023 Nov 2:2023.10.30.564691. doi: 10.1101/2023.10.30.564691. bioRxiv. 2023. Update in: Genome Res. 2024 May 15;34(4):539-555. doi: 10.1101/gr.278680.123 PMID: 37961147 Free PMC article. Updated. Preprint.
Curcuphenol possesses an unusual histone deacetylase enhancing activity that counters immune escape in metastatic tumours.
Ellis SLS, Dada S, Nohara LL, Saranchova I, Munro L, Pfeifer CG, Eyford BA, Morova T, Williams DE, Cheng P, Lack NA, Andersen RJ, Jefferies WA. Ellis SLS, et al. Among authors: morova t. Front Pharmacol. 2023 Aug 10;14:1119620. doi: 10.3389/fphar.2023.1119620. eCollection 2023. Front Pharmacol. 2023. PMID: 37637416 Free PMC article.
Specific cannabinoids revive adaptive immunity by reversing immune evasion mechanisms in metastatic tumours.
Dada S, Ellis SLS, Wood C, Nohara LL, Dreier C, Garcia NH, Saranchova I, Munro L, Pfeifer CG, Eyford BA, Kari S, Garrovillas E, Caspani G, Al Haddad E, Gray PW, Morova T, Lack NA, Andersen RJ, Tjoelker L, Jefferies WA. Dada S, et al. Among authors: morova t. Front Immunol. 2023 Feb 22;13:982082. doi: 10.3389/fimmu.2022.982082. eCollection 2022. Front Immunol. 2023. PMID: 36923728 Free PMC article.
Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential.
Kneppers J, Severson TM, Siefert JC, Schol P, Joosten SEP, Yu IPL, Huang CF, Morova T, Altıntaş UB, Giambartolomei C, Seo JH, Baca SC, Carneiro I, Emberly E, Pasaniuc B, Jerónimo C, Henrique R, Freedman ML, Wessels LFA, Lack NA, Bergman AM, Zwart W. Kneppers J, et al. Among authors: morova t. Nat Commun. 2022 Nov 30;13(1):7367. doi: 10.1038/s41467-022-35135-2. Nat Commun. 2022. PMID: 36450752 Free PMC article.
Genetic determinants of chromatin reveal prostate cancer risk mediated by context-dependent gene regulation.
Baca SC, Singler C, Zacharia S, Seo JH, Morova T, Hach F, Ding Y, Schwarz T, Huang CF, Anderson J, Fay AP, Kalita C, Groha S, Pomerantz MM, Wang V, Linder S, Sweeney CJ, Zwart W, Lack NA, Pasaniuc B, Takeda DY, Gusev A, Freedman ML. Baca SC, et al. Among authors: morova t. Nat Genet. 2022 Sep;54(9):1364-1375. doi: 10.1038/s41588-022-01168-y. Epub 2022 Sep 7. Nat Genet. 2022. PMID: 36071171 Free PMC article.
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