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Two-color coincidence single-molecule pulldown for the specific detection of disease-associated protein aggregates.
Saleeb RS, Leighton C, Lee JE, O'Shaughnessy J, Jeacock K, Chappard A, Cumberland R, Zhao T, Ball SR, Sunde M, Clarke DJ, Piché K, McPhail JA, Louwrier A, Angers R, Gandhi S, Downey P, Kunath T, Horrocks MH. Saleeb RS, et al. Among authors: horrocks mh. Sci Adv. 2023 Nov 17;9(46):eadi7359. doi: 10.1126/sciadv.adi7359. Epub 2023 Nov 15. Sci Adv. 2023. PMID: 37967183 Free PMC article.
Lipid peroxidation is essential for α-synuclein-induced cell death.
Angelova PR, Horrocks MH, Klenerman D, Gandhi S, Abramov AY, Shchepinov MS. Angelova PR, et al. Among authors: horrocks mh. J Neurochem. 2015 May;133(4):582-9. doi: 10.1111/jnc.13024. Epub 2015 Mar 1. J Neurochem. 2015. PMID: 25580849 Free PMC article.
Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease.
Deas E, Cremades N, Angelova PR, Ludtmann MH, Yao Z, Chen S, Horrocks MH, Banushi B, Little D, Devine MJ, Gissen P, Klenerman D, Dobson CM, Wood NW, Gandhi S, Abramov AY. Deas E, et al. Among authors: horrocks mh. Antioxid Redox Signal. 2016 Mar 1;24(7):376-91. doi: 10.1089/ars.2015.6343. Epub 2016 Feb 1. Antioxid Redox Signal. 2016. PMID: 26564470 Free PMC article.
Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids.
Horrocks MH, Lee SF, Gandhi S, Magdalinou NK, Chen SW, Devine MJ, Tosatto L, Kjaergaard M, Beckwith JS, Zetterberg H, Iljina M, Cremades N, Dobson CM, Wood NW, Klenerman D. Horrocks MH, et al. ACS Chem Neurosci. 2016 Mar 16;7(3):399-406. doi: 10.1021/acschemneuro.5b00324. Epub 2016 Feb 4. ACS Chem Neurosci. 2016. PMID: 26800462 Free PMC article.
Ca2+ is a key factor in α-synuclein-induced neurotoxicity.
Angelova PR, Ludtmann MH, Horrocks MH, Negoda A, Cremades N, Klenerman D, Dobson CM, Wood NW, Pavlov EV, Gandhi S, Abramov AY. Angelova PR, et al. Among authors: horrocks mh. J Cell Sci. 2016 May 1;129(9):1792-801. doi: 10.1242/jcs.180737. Epub 2016 Mar 17. J Cell Sci. 2016. PMID: 26989132 Free PMC article.
Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species.
Iljina M, Hong L, Horrocks MH, Ludtmann MH, Choi ML, Hughes CD, Ruggeri FS, Guilliams T, Buell AK, Lee JE, Gandhi S, Lee SF, Bryant CE, Vendruscolo M, Knowles TPJ, Dobson CM, De Genst E, Klenerman D. Iljina M, et al. Among authors: horrocks mh. BMC Biol. 2017 Jul 3;15(1):57. doi: 10.1186/s12915-017-0390-6. BMC Biol. 2017. PMID: 28673288 Free PMC article.
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease.
Ludtmann MHR, Angelova PR, Horrocks MH, Choi ML, Rodrigues M, Baev AY, Berezhnov AV, Yao Z, Little D, Banushi B, Al-Menhali AS, Ranasinghe RT, Whiten DR, Yapom R, Dolt KS, Devine MJ, Gissen P, Kunath T, Jaganjac M, Pavlov EV, Klenerman D, Abramov AY, Gandhi S. Ludtmann MHR, et al. Among authors: horrocks mh. Nat Commun. 2018 Jun 12;9(1):2293. doi: 10.1038/s41467-018-04422-2. Nat Commun. 2018. PMID: 29895861 Free PMC article.
Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells.
Whiten DR, Zuo Y, Calo L, Choi ML, De S, Flagmeier P, Wirthensohn DC, Kundel F, Ranasinghe RT, Sanchez SE, Athauda D, Lee SF, Dobson CM, Gandhi S, Spillantini MG, Klenerman D, Horrocks MH. Whiten DR, et al. Among authors: horrocks mh. Chembiochem. 2018 Oct 4;19(19):2033-2038. doi: 10.1002/cbic.201800209. Epub 2018 Sep 11. Chembiochem. 2018. PMID: 30051958 Free PMC article.
59 results