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Two-color coincidence single-molecule pulldown for the specific detection of disease-associated protein aggregates.
Saleeb RS, Leighton C, Lee JE, O'Shaughnessy J, Jeacock K, Chappard A, Cumberland R, Zhao T, Ball SR, Sunde M, Clarke DJ, Piché K, McPhail JA, Louwrier A, Angers R, Gandhi S, Downey P, Kunath T, Horrocks MH. Saleeb RS, et al. Sci Adv. 2023 Nov 17;9(46):eadi7359. doi: 10.1126/sciadv.adi7359. Epub 2023 Nov 15. Sci Adv. 2023. PMID: 37967183 Free PMC article.
pTDP-43 aggregates accumulate in non-central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis: a case series linking archival surgical biopsies with clinical phenotypic data.
Pattle SB, O'Shaughnessy J, Kantelberg O, Rifai OM, Pate J, Nellany K, Hays N, Arends MJ, Horrocks MH, Waldron FM, Gregory JM. Pattle SB, et al. J Pathol Clin Res. 2023 Jan;9(1):44-55. doi: 10.1002/cjp2.297. Epub 2022 Oct 13. J Pathol Clin Res. 2023. PMID: 36226890 Free PMC article.
RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS.
Spence H, Waldron FM, Saleeb RS, Brown AL, Rifai OM, Gilodi M, Read F, Roberts K, Milne G, Wilkinson D, O'Shaughnessy J, Pastore A, Fratta P, Shneider N, Tartaglia GG, Zacco E, Horrocks MH, Gregory JM. Spence H, et al. Acta Neuropathol. 2024 Mar 5;147(1):50. doi: 10.1007/s00401-024-02705-1. Acta Neuropathol. 2024. PMID: 38443601 Free PMC article.
Advancing alternative methods to reduce animal testing.
Nelson CP, Brown P, Fitzpatrick S, Ford KA, Howard PC, MacGill T, Margerrison EEC, O'Shaughnessy J, Patterson TA, Raghuwanshi R, Rouse R, Stromgren S, Sung KE, Valerio LG Jr, Ward JL, Bumpus NN. Nelson CP, et al. Among authors: o shaughnessy j. Science. 2024 Nov 15;386(6723):724-726. doi: 10.1126/science.adg6228. Epub 2024 Nov 14. Science. 2024. PMID: 39541448
Trastuzumab Duocarmazine in Pretreated Human Epidermal Growth Factor Receptor 2-Positive Advanced or Metastatic Breast Cancer: An Open-Label, Randomized, Phase III Trial (TULIP).
Turner N, Saura C, Aftimos P, van den Tweel E, Oesterholt M, Koper N, Colleoni M, Kaczmarek E, Punie K, Song X, Armstrong A, Bianchi G, Stradella A, Ladoire S, Lim JSJ, Quenel-Tueux N, Tan TJ, Escrivá-de-Romaní S, O'Shaughnessy J; TULIP Trial Investigators. Turner N, et al. Among authors: o shaughnessy j. J Clin Oncol. 2024 Oct 23:JCO2400529. doi: 10.1200/JCO.24.00529. Online ahead of print. J Clin Oncol. 2024. PMID: 39442070
Overall Survival with Pembrolizumab in Early-Stage Triple-Negative Breast Cancer.
Schmid P, Cortes J, Dent R, McArthur H, Pusztai L, Kümmel S, Denkert C, Park YH, Hui R, Harbeck N, Takahashi M, Im SA, Untch M, Fasching PA, Mouret-Reynier MA, Foukakis T, Ferreira M, Cardoso F, Zhou X, Karantza V, Tryfonidis K, Aktan G, O'Shaughnessy J; KEYNOTE-522 Investigators. Schmid P, et al. Among authors: o shaughnessy j. N Engl J Med. 2024 Nov 28;391(21):1981-1991. doi: 10.1056/NEJMoa2409932. Epub 2024 Sep 15. N Engl J Med. 2024. PMID: 39282906 Clinical Trial.
439 results