Tombola F - Search Results

1

Mechanically-primed voltage-gated proton channels from angiosperm plants.

Zhao C, Webster PD, De Angeli A, Tombola F. Zhao C, et al. Among authors: tombola f. Nat Commun. 2023 Nov 18;14(1):7515. doi: 10.1038/s41467-023-43280-5. Nat Commun. 2023. PMID: 37980353 Free PMC article.

2

Voltage-gated proton channels from fungi highlight role of peripheral regions in channel activation.

Zhao C, Tombola F. Zhao C, et al. Among authors: tombola f. Commun Biol. 2021 Feb 26;4(1):261. doi: 10.1038/s42003-021-01792-0. Commun Biol. 2021. PMID: 33637875 Free PMC article.

3

Voltage-dependent structural models of the human Hv1 proton channel from long-timescale molecular dynamics simulations.

Geragotelis AD, Wood ML, Göddeke H, Hong L, Webster PD, Wong EK, Freites JA, Tombola F, Tobias DJ. Geragotelis AD, et al. Among authors: tombola f. Proc Natl Acad Sci U S A. 2020 Jun 16;117(24):13490-13498. doi: 10.1073/pnas.1920943117. Epub 2020 May 27. Proc Natl Acad Sci U S A. 2020. PMID: 32461356 Free PMC article.

4

HIFs: New arginine mimic inhibitors of the Hv1 channel with improved VSD-ligand interactions.

Zhao C, Hong L, Galpin JD, Riahi S, Lim VT, Webster PD, Tobias DJ, Ahern CA, Tombola F. Zhao C, et al. Among authors: tombola f. J Gen Physiol. 2021 Sep 6;153(9):e202012832. doi: 10.1085/jgp.202012832. Epub 2021 Jul 6. J Gen Physiol. 2021. PMID: 34228044 Free PMC article.

5

A novel Hv1 inhibitor reveals a new mechanism of inhibition of a voltage-sensing domain.

Zhao C, Hong L, Riahi S, Lim VT, Tobias DJ, Tombola F. Zhao C, et al. Among authors: tombola f. J Gen Physiol. 2021 Sep 6;153(9):e202012833. doi: 10.1085/jgp.202012833. Epub 2021 Jul 6. J Gen Physiol. 2021. PMID: 34228045 Free PMC article.

6

The opening of the two pores of the Hv1 voltage-gated proton channel is tuned by cooperativity.

Tombola F, Ulbrich MH, Kohout SC, Isacoff EY. Tombola F, et al. Nat Struct Mol Biol. 2010 Jan;17(1):44-50. doi: 10.1038/nsmb.1738. Epub 2009 Dec 20. Nat Struct Mol Biol. 2010. PMID: 20023640 Free PMC article.

7

Voltage-sensing domain of voltage-gated proton channel Hv1 shares mechanism of block with pore domains.

Hong L, Pathak MM, Kim IH, Ta D, Tombola F. Hong L, et al. Among authors: tombola f. Neuron. 2013 Jan 23;77(2):274-87. doi: 10.1016/j.neuron.2012.11.013. Neuron. 2013. PMID: 23352164 Free PMC article.

8

The twisted ion-permeation pathway of a resting voltage-sensing domain.

Tombola F, Pathak MM, Gorostiza P, Isacoff EY. Tombola F, et al. Nature. 2007 Feb 1;445(7127):546-9. doi: 10.1038/nature05396. Epub 2006 Dec 24. Nature. 2007. PMID: 17187057

9

Architecture and gating of Hv1 proton channels.

Tombola F, Ulbrich MH, Isacoff EY. Tombola F, et al. J Physiol. 2009 Nov 15;587(Pt 22):5325-9. doi: 10.1113/jphysiol.2009.180265. J Physiol. 2009. PMID: 19915215 Free PMC article. Review.

10

Evidence for functional diversity between the voltage-gated proton channel Hv1 and its closest related protein HVRP1.

Kim IH, Hevezi P, Varga C, Pathak MM, Hong L, Ta D, Tran CT, Zlotnik A, Soltesz I, Tombola F. Kim IH, et al. Among authors: tombola f. PLoS One. 2014 Aug 28;9(8):e105926. doi: 10.1371/journal.pone.0105926. eCollection 2014. PLoS One. 2014. PMID: 25165868 Free PMC article.

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