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RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS.
Shimizu M, Shiraishi N, Tada S, Sasaki T, Beck G, Nagano S, Kinoshita M, Sumi H, Sugimoto T, Ishida Y, Koda T, Ishikura T, Sugiyama Y, Kihara K, Kanakura M, Nakajima T, Takeda S, Takahashi MP, Yamashita T, Okuno T, Mochizuki H. Shimizu M, et al. Among authors: yamashita t. Sci Adv. 2023 Nov 24;9(47):eadg3193. doi: 10.1126/sciadv.adg3193. Epub 2023 Nov 22. Sci Adv. 2023. PMID: 37992159 Free PMC article.
Reduction of brain beta-amyloid (Abeta) by fluvastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, through increase in degradation of amyloid precursor protein C-terminal fragments (APP-CTFs) and Abeta clearance.
Shinohara M, Sato N, Kurinami H, Takeuchi D, Takeda S, Shimamura M, Yamashita T, Uchiyama Y, Rakugi H, Morishita R. Shinohara M, et al. Among authors: yamashita t. J Biol Chem. 2010 Jul 16;285(29):22091-102. doi: 10.1074/jbc.M110.102277. Epub 2010 May 14. J Biol Chem. 2010. PMID: 20472556 Free PMC article.
RGMa modulates T cell responses and is involved in autoimmune encephalomyelitis.
Muramatsu R, Kubo T, Mori M, Nakamura Y, Fujita Y, Akutsu T, Okuno T, Taniguchi J, Kumanogoh A, Yoshida M, Mochizuki H, Kuwabara S, Yamashita T. Muramatsu R, et al. Among authors: yamashita t. Nat Med. 2011 Apr;17(4):488-94. doi: 10.1038/nm.2321. Epub 2011 Mar 20. Nat Med. 2011. PMID: 21423182
Activated microglia inhibit axonal growth through RGMa.
Kitayama M, Ueno M, Itakura T, Yamashita T. Kitayama M, et al. Among authors: yamashita t. PLoS One. 2011;6(9):e25234. doi: 10.1371/journal.pone.0025234. Epub 2011 Sep 21. PLoS One. 2011. PMID: 21957482 Free PMC article.
Peripherally derived FGF21 promotes remyelination in the central nervous system.
Kuroda M, Muramatsu R, Maedera N, Koyama Y, Hamaguchi M, Fujimura H, Yoshida M, Konishi M, Itoh N, Mochizuki H, Yamashita T. Kuroda M, et al. Among authors: yamashita t. J Clin Invest. 2017 Sep 1;127(9):3496-3509. doi: 10.1172/JCI94337. Epub 2017 Aug 21. J Clin Invest. 2017. PMID: 28825598 Free PMC article.
6,909 results