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Application of machine learning models to identify serological predictors of COVID-19 severity and outcomes.
Klein S, Dhakal S, Yin A, Escarra-Senmarti M, Demko Z, Pisanic N, Johnston T, Trejo-Zambrano M, Kruczynski K, Lee J, Hardick J, Shea P, Shapiro J, Park HS, Parish M, Caputo C, Ganesan A, Mullapudi S, Gould S, Betenbaugh M, Pekosz A, Heaney CD, Antar A, Manabe Y, Cox A, Karaba A, Andrade F, Zeger S. Klein S, et al. Among authors: cox a. Res Sq [Preprint]. 2023 Nov 13:rs.3.rs-3463155. doi: 10.21203/rs.3.rs-3463155/v1. Res Sq. 2023. Update in: Commun Med (Lond). 2024 Nov 26;4(1):249. doi: 10.1038/s43856-024-00658-w PMID: 38014049 Free PMC article. Updated. Preprint.
Metabolic programs define dysfunctional immune responses in severe COVID-19 patients.
Thompson EA, Cascino K, Ordonez AA, Zhou W, Vaghasia A, Hamacher-Brady A, Brady NR, Sun IH, Wang R, Rosenberg AZ, Delannoy M, Rothman R, Fenstermacher K, Sauer L, Shaw-Saliba K, Bloch EM, Redd AD, Tobian AA, Horton M, Smith K, Pekosz A, D'Alessio FR, Yegnasubramanian S, Ji H, Cox AL, Powell JD. Thompson EA, et al. Among authors: cox al. medRxiv [Preprint]. 2020 Oct 5:2020.09.10.20186064. doi: 10.1101/2020.09.10.20186064. medRxiv. 2020. Update in: Cell Rep. 2021 Mar 16;34(11):108863. doi: 10.1016/j.celrep.2021.108863 PMID: 32935120 Free PMC article. Updated. Preprint.
IgM autoantibodies recognizing ACE2 are associated with severe COVID-19.
Casciola-Rosen L, Thiemann DR, Andrade F, Trejo Zambrano MI, Hooper JE, Leonard EK, Spangler JB, Cox AL, Machamer CE, Sauer L, Laeyendecker O, Garibaldi BT, Ray SC, Mecoli CA, Christopher-Stine L, Gutierrez-Alamillo L, Yang Q, Hines D, Clarke WA, Rothman R, Pekosz A, Fenstermacher KJ, Wang Z, Zeger SL, Rosen A. Casciola-Rosen L, et al. Among authors: cox al. medRxiv [Preprint]. 2020 Oct 15:2020.10.13.20211664. doi: 10.1101/2020.10.13.20211664. medRxiv. 2020. Update in: JCI Insight. 2022 May 9;7(9):e158362. doi: 10.1172/jci.insight.158362 PMID: 33083808 Free PMC article. Updated. Preprint.
Durable SARS-CoV-2 B cell immunity after mild or severe disease.
Ogega CO, Skinner NE, Blair PW, Park HS, Littlefield K, Ganesan A, Ladiwala P, Antar AA, Ray SC, Betenbaugh MJ, Pekosz A, Klein SL, Manabe YC, Cox AL, Bailey JR. Ogega CO, et al. Among authors: cox al. medRxiv [Preprint]. 2020 Oct 30:2020.10.28.20220996. doi: 10.1101/2020.10.28.20220996. medRxiv. 2020. Update in: J Clin Invest. 2021 Apr 1;131(7):145516. doi: 10.1172/JCI145516 PMID: 33140070 Free PMC article. Updated. Preprint.
Durable SARS-CoV-2 B cell immunity after mild or severe disease.
Ogega CO, Skinner NE, Blair PW, Park HS, Littlefield K, Ganesan A, Dhakal S, Ladiwala P, Antar AA, Ray SC, Betenbaugh MJ, Pekosz A, Klein SL, Manabe YC, Cox AL, Bailey JR. Ogega CO, et al. Among authors: cox al. J Clin Invest. 2021 Apr 1;131(7):e145516. doi: 10.1172/JCI145516. J Clin Invest. 2021. PMID: 33571162 Free PMC article.
The Clinical Course of COVID-19 in the Outpatient Setting: A Prospective Cohort Study.
Blair PW, Brown DM, Jang M, Antar AAR, Keruly JC, Bachu VS, Townsend JL, Tornheim JA, Keller SC, Sauer L, Thomas DL, Manabe YC; Ambulatory COVID Study Team. Blair PW, et al. Open Forum Infect Dis. 2021 Jan 5;8(2):ofab007. doi: 10.1093/ofid/ofab007. eCollection 2021 Feb. Open Forum Infect Dis. 2021. PMID: 33614816 Free PMC article.
Delayed rise of oral fluid antibodies, elevated BMI, and absence of early fever correlate with longer time to SARS-CoV-2 RNA clearance in an longitudinally sampled cohort of COVID-19 outpatients.
Antar AAR, Yu T, Pisanic N, Azamfirei R, Tornheim JA, Brown DM, Kruczynski K, Hardick JP, Sewell T, Jang M, Church T, Walch SN, Reuland C, Bachu VS, Littlefield K, Park HS, Ursin RL, Ganesan A, Kusemiju O, Barnaba B, Charles C, Prizzi M, Johnstone JR, Payton C, Dai W, Fuchs J, Massaccesi G, Armstrong DT, Townsend JL, Keller SC, Demko ZO, Hu C, Wang MC, Sauer LM, Mostafa HH, Keruly JC, Mehta SH, Klein SL, Cox AL, Pekosz A, Heaney CD, Thomas DL, Blair PW, Manabe YC. Antar AAR, et al. Among authors: cox al. medRxiv [Preprint]. 2021 Mar 3:2021.03.02.21252420. doi: 10.1101/2021.03.02.21252420. medRxiv. 2021. Update in: Open Forum Infect Dis. 2021 Apr 16;8(6):ofab195. doi: 10.1093/ofid/ofab195 PMID: 33688688 Free PMC article. Updated. Preprint.
METHODS: Ninety-five outpatients self-collected mid-turbinate nasal, oropharyngeal (OP), and gingival crevicular fluid (oral fluid) samples at home and in a research clinic a median of 6 times over 1-3 months. Samples were tested for viral RNA, virus culture, and SA …
METHODS: Ninety-five outpatients self-collected mid-turbinate nasal, oropharyngeal (OP), and gingival crevicular fluid (oral fluid) samples …
Metabolic programs define dysfunctional immune responses in severe COVID-19 patients.
Thompson EA, Cascino K, Ordonez AA, Zhou W, Vaghasia A, Hamacher-Brady A, Brady NR, Sun IH, Wang R, Rosenberg AZ, Delannoy M, Rothman R, Fenstermacher K, Sauer L, Shaw-Saliba K, Bloch EM, Redd AD, Tobian AAR, Horton M, Smith K, Pekosz A, D'Alessio FR, Yegnasubramanian S, Ji H, Cox AL, Powell JD. Thompson EA, et al. Among authors: cox al. Cell Rep. 2021 Mar 16;34(11):108863. doi: 10.1016/j.celrep.2021.108863. Epub 2021 Feb 26. Cell Rep. 2021. PMID: 33691089 Free PMC article.
Differential Cytokine Signatures of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Influenza Infection Highlight Key Differences in Pathobiology.
Karaba AH, Zhou W, Hsieh LL, Figueroa A, Massaccesi G, Rothman RE, Fenstermacher KZJ, Sauer L, Shaw-Saliba K, Blair PW, Robinson ML, Leung S, Wesson R, Alachkar N, El-Diwany R, Ji H, Cox AL. Karaba AH, et al. Among authors: cox al. Clin Infect Dis. 2022 Jan 29;74(2):254-262. doi: 10.1093/cid/ciab376. Clin Infect Dis. 2022. PMID: 34013339 Free PMC article.
2,704 results