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Proteome-wide base editor screens to assess phosphorylation site functionality in high-throughput.
Kennedy PH, Deh Sheikh AA, Balakar M, Jones AC, Olive ME, Hegde M, Matias MI, Pirete N, Burt R, Levy J, Little T, Hogan PG, Liu DR, Doench JG, Newton AC, Gottschalk RA, de Boer C, Alarcón S, Newby G, Myers SA. Kennedy PH, et al. Among authors: hegde m. bioRxiv [Preprint]. 2023 Nov 14:2023.11.11.566649. doi: 10.1101/2023.11.11.566649. bioRxiv. 2023. Update in: Nat Methods. 2024 Jun;21(6):1033-1043. doi: 10.1038/s41592-024-02256-z PMID: 38014346 Free PMC article. Updated. Preprint.
Massively parallel assessment of human variants with base editor screens.
Hanna RE, Hegde M, Fagre CR, DeWeirdt PC, Sangree AK, Szegletes Z, Griffith A, Feeley MN, Sanson KR, Baidi Y, Koblan LW, Liu DR, Neal JT, Doench JG. Hanna RE, et al. Among authors: hegde m. Cell. 2021 Feb 18;184(4):1064-1080.e20. doi: 10.1016/j.cell.2021.01.012. Cell. 2021. PMID: 33606977 Free article.
Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal coronaviruses.
Rebendenne A, Roy P, Bonaventure B, Chaves Valadão AL, Desmarets L, Rouillé Y, Tauziet M, Arnaud-Arnould M, Giovannini D, Lee Y, DeWeirdt P, Hegde M, Garcia de Gracia F, McKellar J, Wencker M, Dubuisson J, Belouzard S, Moncorgé O, Doench JG, Goujon C. Rebendenne A, et al. Among authors: hegde m. bioRxiv [Preprint]. 2021 May 21:2021.05.19.444823. doi: 10.1101/2021.05.19.444823. bioRxiv. 2021. Update in: Nat Genet. 2022 Aug;54(8):1090-1102. doi: 10.1038/s41588-022-01110-2 PMID: 34031654 Free PMC article. Updated. Preprint.
Post-translational modification-centric base editor screens to assess phosphorylation site functionality in high throughput.
Kennedy PH, Alborzian Deh Sheikh A, Balakar M, Jones AC, Olive ME, Hegde M, Matias MI, Pirete N, Burt R, Levy J, Little T, Hogan PG, Liu DR, Doench JG, Newton AC, Gottschalk RA, de Boer CG, Alarcón S, Newby GA, Myers SA. Kennedy PH, et al. Among authors: hegde m. Nat Methods. 2024 Jun;21(6):1033-1043. doi: 10.1038/s41592-024-02256-z. Epub 2024 Apr 29. Nat Methods. 2024. PMID: 38684783
685 results