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Label-free affinity screening, design and synthesis of inhibitors targeting the Mycobacterium tuberculosis L-alanine dehydrogenase.
Kim HB, Bacik JP, Wu R, Jha RK, Hebron M, Triandafillou C, McCown JE, Baek NI, Kim JH, Kim YJ, Goulding CW, Strauss CEM, Schmidt JG, Shetye GS, Ryoo S, Jo EK, Jeon YH, Hung LW, Terwilliger TC, Kim CY. Kim HB, et al. Among authors: bacik jp. PLoS One. 2022 Nov 17;17(11):e0277670. doi: 10.1371/journal.pone.0277670. eCollection 2022. PLoS One. 2022. PMID: 36395154 Free PMC article.
The flexible N-terminus of BchL autoinhibits activity through interaction with its [4Fe-4S] cluster and released upon ATP binding.
Corless EI, Saad Imran SM, Watkins MB, Bacik JP, Mattice JR, Patterson A, Danyal K, Soffe M, Kitelinger R, Seefeldt LC, Origanti S, Bennett B, Bothner B, Ando N, Antony E. Corless EI, et al. Among authors: bacik jp. J Biol Chem. 2021 Jan-Jun;296:100107. doi: 10.1074/jbc.RA120.016278. Epub 2020 Dec 3. J Biol Chem. 2021. PMID: 33219127 Free PMC article.
Convergent allostery in ribonucleotide reductase.
Thomas WC, Brooks FP 3rd, Burnim AA, Bacik JP, Stubbe J, Kaelber JT, Chen JZ, Ando N. Thomas WC, et al. Among authors: bacik jp. Nat Commun. 2019 Jun 14;10(1):2653. doi: 10.1038/s41467-019-10568-4. Nat Commun. 2019. PMID: 31201319 Free PMC article.
27 results