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BAK core dimers bind lipids and can be bridged by them.
Cowan AD, Smith NA, Sandow JJ, Kapp EA, Rustam YH, Murphy JM, Brouwer JM, Bernardini JP, Roy MJ, Wardak AZ, Tan IK, Webb AI, Gulbis JM, Smith BJ, Reid GE, Dewson G, Colman PM, Czabotar PE. Cowan AD, et al. Among authors: colman pm. Nat Struct Mol Biol. 2020 Nov;27(11):1024-1031. doi: 10.1038/s41594-020-0494-5. Epub 2020 Sep 14. Nat Struct Mol Biol. 2020. PMID: 32929280
The Bak core dimer focuses triacylglycerides in the membrane.
Smith NA, Wardak AZ, Cowan AD, Colman PM, Czabotar PE, Smith BJ. Smith NA, et al. Among authors: colman pm. Biophys J. 2022 Feb 1;121(3):347-360. doi: 10.1016/j.bpj.2021.12.043. Epub 2021 Dec 30. Biophys J. 2022. PMID: 34973947 Free PMC article.
Bax activation by Bim?
Czabotar PE, Colman PM, Huang DC. Czabotar PE, et al. Among authors: colman pm. Cell Death Differ. 2009 Sep;16(9):1187-91. doi: 10.1038/cdd.2009.83. Epub 2009 Jun 26. Cell Death Differ. 2009. PMID: 19557009 Review.
Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Brouwer JM, Lan P, Cowan AD, Bernardini JP, Birkinshaw RW, van Delft MF, Sleebs BE, Robin AY, Wardak A, Tan IK, Reljic B, Lee EF, Fairlie WD, Call MJ, Smith BJ, Dewson G, Lessene G, Colman PM, Czabotar PE. Brouwer JM, et al. Among authors: colman pm. Mol Cell. 2017 Nov 16;68(4):659-672.e9. doi: 10.1016/j.molcel.2017.11.001. Mol Cell. 2017. PMID: 29149594 Free article.
Ensemble Properties of Bax Determine Its Function.
Robin AY, Iyer S, Birkinshaw RW, Sandow J, Wardak A, Luo CS, Shi M, Webb AI, Czabotar PE, Kluck RM, Colman PM. Robin AY, et al. Among authors: colman pm. Structure. 2018 Oct 2;26(10):1346-1359.e5. doi: 10.1016/j.str.2018.07.006. Epub 2018 Aug 16. Structure. 2018. PMID: 30122452 Free article.
Structure of detergent-activated BAK dimers derived from the inert monomer.
Birkinshaw RW, Iyer S, Lio D, Luo CS, Brouwer JM, Miller MS, Robin AY, Uren RT, Dewson G, Kluck RM, Colman PM, Czabotar PE. Birkinshaw RW, et al. Among authors: colman pm. Mol Cell. 2021 May 20;81(10):2123-2134.e5. doi: 10.1016/j.molcel.2021.03.014. Epub 2021 Mar 31. Mol Cell. 2021. PMID: 33794146 Free article.
141 results