Uren RT - Search Results

1

Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.

Miller MS, Cowan AD, Brouwer JM, Smyth ST, Peng L, Wardak AZ, Uren RT, Luo C, Roy MJ, Shah S, Tan Z, Reid GE, Colman PM, Czabotar PE. Miller MS, et al. Among authors: uren rt. FEBS J. 2024 Jun;291(11):2335-2353. doi: 10.1111/febs.17031. Epub 2024 Jan 19. FEBS J. 2024. PMID: 38088212

2

Bak core and latch domains separate during activation, and freed core domains form symmetric homodimers.

Brouwer JM, Westphal D, Dewson G, Robin AY, Uren RT, Bartolo R, Thompson GV, Colman PM, Kluck RM, Czabotar PE. Brouwer JM, et al. Among authors: uren rt. Mol Cell. 2014 Sep 18;55(6):938-946. doi: 10.1016/j.molcel.2014.07.016. Epub 2014 Aug 28. Mol Cell. 2014. PMID: 25175025 Free article.

3

Disordered clusters of Bak dimers rupture mitochondria during apoptosis.

Uren RT, O'Hely M, Iyer S, Bartolo R, Shi MX, Brouwer JM, Alsop AE, Dewson G, Kluck RM. Uren RT, et al. Elife. 2017 Feb 6;6:e19944. doi: 10.7554/eLife.19944. Elife. 2017. PMID: 28182867 Free PMC article.

4

Pore formation by dimeric Bak and Bax: an unusual pore?

Uren RT, Iyer S, Kluck RM. Uren RT, et al. Philos Trans R Soc Lond B Biol Sci. 2017 Aug 5;372(1726):20160218. doi: 10.1098/rstb.2016.0218. Philos Trans R Soc Lond B Biol Sci. 2017. PMID: 28630157 Free PMC article. Review.

5

Structure of detergent-activated BAK dimers derived from the inert monomer.

Birkinshaw RW, Iyer S, Lio D, Luo CS, Brouwer JM, Miller MS, Robin AY, Uren RT, Dewson G, Kluck RM, Colman PM, Czabotar PE. Birkinshaw RW, et al. Among authors: uren rt. Mol Cell. 2021 May 20;81(10):2123-2134.e5. doi: 10.1016/j.molcel.2021.03.014. Epub 2021 Mar 31. Mol Cell. 2021. PMID: 33794146 Free article.

6

A novel inhibitory BAK antibody enables assessment of non-activated BAK in cancer cells.

Subas Satish HP, Iyer S, Shi MX, Wong AW, Fischer KC, Wardak AZ, Lio D, Brouwer JM, Uren RT, Czabotar PE, Miller MS, Kluck RM. Subas Satish HP, et al. Among authors: uren rt. Cell Death Differ. 2024 Jun;31(6):711-721. doi: 10.1038/s41418-024-01289-3. Epub 2024 Apr 6. Cell Death Differ. 2024. PMID: 38582955 Free PMC article.

7

Probing BAK and BAX Activation and Pore Assembly with Cytochrome c Release, Limited Proteolysis, and Oxidant-Induced Linkage.

Iyer S, Uren RT, Kluck RM. Iyer S, et al. Among authors: uren rt. Methods Mol Biol. 2019;1877:201-216. doi: 10.1007/978-1-4939-8861-7_14. Methods Mol Biol. 2019. PMID: 30536008

8

Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target.

Iyer S, Uren RT, Dengler MA, Shi MX, Uno E, Adams JM, Dewson G, Kluck RM. Iyer S, et al. Among authors: uren rt. Cell Death Dis. 2020 Apr 23;11(4):268. doi: 10.1038/s41419-020-2463-7. Cell Death Dis. 2020. PMID: 32327636 Free PMC article.

9

The BCL-2 family member BID plays a role during embryonic development in addition to its BH3-only protein function by acting in parallel to BAX, BAK and BOK.

Ke FS, Holloway S, Uren RT, Wong AW, Little MH, Kluck RM, Voss AK, Strasser A. Ke FS, et al. Among authors: uren rt. EMBO J. 2022 Aug 1;41(15):e110300. doi: 10.15252/embj.2021110300. Epub 2022 Jun 27. EMBO J. 2022. PMID: 35758142 Free PMC article.

10

Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak.

Uren RT, Dewson G, Chen L, Coyne SC, Huang DC, Adams JM, Kluck RM. Uren RT, et al. J Cell Biol. 2007 Apr 23;177(2):277-87. doi: 10.1083/jcb.200606065. J Cell Biol. 2007. PMID: 17452531 Free PMC article.

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