Lee KH - Search Results

1

Modifications to 1-(4-(2-Bis(4-fluorophenyl)methyl)sulfinyl)alkyl Alicyclic Amines That Improve Metabolic Stability and Retain an Atypical DAT Inhibitor Profile.

Okorom AV, Camacho-Hernandez GA, Salomon K, Lee KH, Ku TC, Cao J, Won SJ, Friedman J, Lam J, Paule J, Rais R, Klein B, Xi ZX, Shi L, Loland CJ, Newman AH. Okorom AV, et al. Among authors: lee kh. J Med Chem. 2024 Jan 11;67(1):709-727. doi: 10.1021/acs.jmedchem.3c02037. Epub 2023 Dec 20. J Med Chem. 2024. PMID: 38117239

2

Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism.

Lane JR, Abramyan AM, Adhikari P, Keen AC, Lee KH, Sanchez J, Verma RK, Lim HD, Yano H, Javitch JA, Shi L. Lane JR, et al. Among authors: lee kh. Elife. 2020 Jan 27;9:e52189. doi: 10.7554/eLife.52189. Elife. 2020. PMID: 31985399 Free PMC article.

3

Toward Reducing hERG Affinities for DAT Inhibitors with a Combined Machine Learning and Molecular Modeling Approach.

Lee KH, Fant AD, Guo J, Guan A, Jung J, Kudaibergenova M, Miranda WE, Ku T, Cao J, Wacker S, Duff HJ, Newman AH, Noskov SY, Shi L. Lee KH, et al. J Chem Inf Model. 2021 Sep 27;61(9):4266-4279. doi: 10.1021/acs.jcim.1c00856. Epub 2021 Aug 21. J Chem Inf Model. 2021. PMID: 34420294 Free PMC article.

4

Structure Activity Relationships for a Series of Eticlopride-Based Dopamine D₂/D₃ Receptor Bitopic Ligands.

Shaik AB, Boateng CA, Battiti FO, Bonifazi A, Cao J, Chen L, Chitsazi R, Ravi S, Lee KH, Shi L, Newman AH. Shaik AB, et al. Among authors: lee kh. J Med Chem. 2021 Oct 28;64(20):15313-15333. doi: 10.1021/acs.jmedchem.1c01353. Epub 2021 Oct 12. J Med Chem. 2021. PMID: 34636551 Free PMC article.

5

Disentangling autoproteolytic cleavage from tethered agonist-dependent activation of the adhesion receptor ADGRL3.

Perry-Hauser NA, VanDyck MW, Lee KH, Shi L, Javitch JA. Perry-Hauser NA, et al. Among authors: lee kh. J Biol Chem. 2022 Dec;298(12):102594. doi: 10.1016/j.jbc.2022.102594. Epub 2022 Oct 14. J Biol Chem. 2022. PMID: 36244455 Free PMC article.

6

Identification and Characterization of ML321: A Novel and Highly Selective D₂ Dopamine Receptor Antagonist with Efficacy in Animal Models That Predict Atypical Antipsychotic Activity.

Free RB, Nilson AN, Boldizsar NM, Doyle TB, Rodriguiz RM, Pogorelov VM, Machino M, Lee KH, Bertz JW, Xu J, Lim HD, Dulcey AE, Mach RH, Woods JH, Lane JR, Shi L, Marugan JJ, Wetsel WC, Sibley DR. Free RB, et al. Among authors: lee kh. ACS Pharmacol Transl Sci. 2022 Dec 30;6(1):151-170. doi: 10.1021/acsptsci.2c00202. eCollection 2023 Jan 13. ACS Pharmacol Transl Sci. 2022. PMID: 36654757 Free PMC article.

7

A Novel "Activation Switch" Motif Common to All Aminergic Receptors.

Lee KH, Manning JJ, Javitch J, Shi L. Lee KH, et al. J Chem Inf Model. 2023 Aug 28;63(16):5001-5017. doi: 10.1021/acs.jcim.3c00732. Epub 2023 Aug 4. J Chem Inf Model. 2023. PMID: 37540602 Free PMC article. Review.

8

Unraveling activation-related rearrangements and intrinsic divergence from ligand-induced conformational changes of the dopamine D3 and D2 receptors.

Lee KH, Shi L. Lee KH, et al. bioRxiv [Preprint]. 2023 Nov 14:2023.11.11.566699. doi: 10.1101/2023.11.11.566699. bioRxiv. 2023. Update in: J Chem Inf Model. 2024 Mar 25;64(6):1778-1793. doi: 10.1021/acs.jcim.3c01956 PMID: 38014309 Free PMC article. Updated. Preprint.

9

Series of (([1,1'-Biphenyl]-2-yl)methyl)sulfinylalkyl Alicyclic Amines as Novel and High Affinity Atypical Dopamine Transporter Inhibitors with Reduced hERG Activity.

Ku TC, Cao J, Won SJ, Guo J, Camacho-Hernandez GA, Okorom AV, Salomon KW, Lee KH, Loland CJ, Duff HJ, Shi L, Newman AH. Ku TC, et al. Among authors: lee kh. ACS Pharmacol Transl Sci. 2024 Jan 5;7(2):515-532. doi: 10.1021/acsptsci.3c00322. eCollection 2024 Feb 9. ACS Pharmacol Transl Sci. 2024. PMID: 38357284

10

Unraveling Activation-Related Rearrangements and Intrinsic Divergence from Ligand-Specific Conformational Changes of the Dopamine D3 and D2 Receptors.

Lee KH, Shi L. Lee KH, et al. J Chem Inf Model. 2024 Mar 25;64(6):1778-1793. doi: 10.1021/acs.jcim.3c01956. Epub 2024 Mar 7. J Chem Inf Model. 2024. PMID: 38454785 Review.

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