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Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts.
Zhou W, Karan KR, Gu W, Klein HU, Sturm G, De Jager PL, Bennett DA, Hirano M, Picard M, Mills RE. Zhou W, et al. Among authors: klein hu. bioRxiv [Preprint]. 2023 Apr 21:2023.02.03.527065. doi: 10.1101/2023.02.03.527065. bioRxiv. 2023. Update in: PLoS Biol. 2024 Aug 22;22(8):e3002723. doi: 10.1371/journal.pbio.3002723 PMID: 36778249 Free PMC article. Updated. Preprint.
Cell-type-specific regulation of APOE levels in human neurons by the Alzheimer's disease risk gene SORL1.
Lee H, Aylward AJ, Pearse RV, Hsieh YC, Augur ZM, Benoit CR, Chou V, Knupp A, Pan C, Goberdhan S, Duong DM, Seyfried NT, Bennett DA, Klein HU, De Jager PL, Menon V, Young JE, Young-Pearse TL. Lee H, et al. Among authors: klein hu. bioRxiv [Preprint]. 2023 Feb 25:2023.02.25.530017. doi: 10.1101/2023.02.25.530017. bioRxiv. 2023. Update in: Cell Rep. 2023 Aug 29;42(8):112994. doi: 10.1016/j.celrep.2023.112994 PMID: 36865313 Free PMC article. Updated. Preprint.
ZCCHC17 modulates neuronal RNA splicing and supports cognitive resilience in Alzheimer's disease.
Bartosch AMW, Youth EHH, Hansen S, Kaufman ME, Xiao H, Koo SY, Ashok A, Sivakumar S, Soni RK, Dumitrescu LC, Lam TG, Ropri AS, Lee AJ, Klein HU, Vardarajan BN, Bennett DA, Young-Pearse TL, De Jager PL, Hohman TJ, Sproul AA, Teich AF. Bartosch AMW, et al. Among authors: klein hu. bioRxiv [Preprint]. 2023 Mar 21:2023.03.21.533654. doi: 10.1101/2023.03.21.533654. bioRxiv. 2023. Update in: J Neurosci. 2024 Jan 17;44(3):e2324222023. doi: 10.1523/JNEUROSCI.2324-22.2023 PMID: 36993746 Free PMC article. Updated. Preprint.
A single-nucleus transcriptome-wide association study implicates novel genes in depression pathogenesis.
Zeng L, Fujita M, Gao Z, White CC, Green GS, Habib N, Menon V, Bennett DA, Boyle PA, Klein HU, De Jager PL. Zeng L, et al. Among authors: klein hu. medRxiv [Preprint]. 2023 Mar 29:2023.03.27.23286844. doi: 10.1101/2023.03.27.23286844. medRxiv. 2023. Update in: Biol Psychiatry. 2024 Jul 1;96(1):34-43. doi: 10.1016/j.biopsych.2023.12.012 PMID: 37034737 Free PMC article. Updated. Preprint.
Cell-type-specific Alzheimer's disease polygenic risk scores are associated with distinct disease processes in Alzheimer's disease.
Yang HS, Teng L, Kang D, Menon V, Ge T, Finucane HK, Schultz AP, Properzi M, Klein HU, Chibnik LB, Schneider JA, Bennett DA, Hohman TJ, Mayeux RP, Johnson KA, De Jager PL, Sperling RA. Yang HS, et al. Among authors: klein hu. medRxiv [Preprint]. 2023 Jun 5:2023.06.01.23290850. doi: 10.1101/2023.06.01.23290850. medRxiv. 2023. Update in: Nat Commun. 2023 Nov 30;14(1):7659. doi: 10.1038/s41467-023-43132-2 PMID: 37333223 Free PMC article. Updated. Preprint.
Psychosocial experiences are associated with human brain mitochondrial biology.
Trumpff C, Monzel AS, Sandi C, Menon V, Klein HU, Fujita M, Lee A, Petyuk VA, Hurst C, Duong DM, Seyfried NT, Wingo AP, Wingo TS, Wang Y, Thambisetty M, Ferrucci L, Bennett DA, De Jager PL, Picard M. Trumpff C, et al. Among authors: klein hu. Proc Natl Acad Sci U S A. 2024 Jul 2;121(27):e2317673121. doi: 10.1073/pnas.2317673121. Epub 2024 Jun 18. Proc Natl Acad Sci U S A. 2024. PMID: 38889126 Free PMC article.
254 results