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Splicing modulators impair DNA damage response and induce killing of cohesin-mutant MDS and AML.
Wheeler EC, Martin BJE, Doyle WC, Neaher S, Conway CA, Pitton CN, Gorelov RA, Donahue M, Jann JC, Abdel-Wahab O, Taylor J, Seiler M, Buonamici S, Pikman Y, Garcia JS, Belizaire R, Adelman K, Tothova Z. Wheeler EC, et al. Among authors: tothova z. Sci Transl Med. 2024 Jan 3;16(728):eade2774. doi: 10.1126/scitranslmed.ade2774. Epub 2024 Jan 3. Sci Transl Med. 2024. PMID: 38170787 Free PMC article.
STAT5 as a Key Protein of Erythropoietin Signalization.
Tóthová Z, Tomc J, Debeljak N, Solár P. Tóthová Z, et al. Int J Mol Sci. 2021 Jul 1;22(13):7109. doi: 10.3390/ijms22137109. Int J Mol Sci. 2021. PMID: 34281163 Free PMC article. Review.
[FoxO: stress or eternal life].
Tothova Z, Mercher T. Tothova Z, et al. Med Sci (Paris). 2007 May;23(5):466-7. doi: 10.1051/medsci/2007235466. Med Sci (Paris). 2007. PMID: 17502057 Free article. French. No abstract available.
The retinoblastoma binding protein RBP2 is an H3K4 demethylase.
Klose RJ, Yan Q, Tothova Z, Yamane K, Erdjument-Bromage H, Tempst P, Gilliland DG, Zhang Y, Kaelin WG Jr. Klose RJ, et al. Among authors: tothova z. Cell. 2007 Mar 9;128(5):889-900. doi: 10.1016/j.cell.2007.02.013. Epub 2007 Feb 22. Cell. 2007. PMID: 17320163 Free article.
Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML.
Tothova Z, Valton AL, Gorelov RA, Vallurupalli M, Krill-Burger JM, Holmes A, Landers CC, Haydu JE, Malolepsza E, Hartigan C, Donahue M, Popova KD, Koochaki S, Venev SV, Rivera J, Chen E, Lage K, Schenone M, D'Andrea AD, Carr SA, Morgan EA, Dekker J, Ebert BL. Tothova Z, et al. JCI Insight. 2021 Feb 8;6(3):e142149. doi: 10.1172/jci.insight.142149. JCI Insight. 2021. PMID: 33351783 Free PMC article.
Cohesin mutations in myeloid malignancies.
Jann JC, Tothova Z. Jann JC, et al. Among authors: tothova z. Blood. 2021 Aug 26;138(8):649-661. doi: 10.1182/blood.2019004259. Blood. 2021. PMID: 34157074 Free PMC article. Review.
Subunit-specific analysis of cohesin-mutant myeloid malignancies reveals distinct ontogeny and outcomes.
Jann JC, Hergott CB, Winkler M, Liu Y, Braun B, Charles A, Copson KM, Barua S, Meggendorfer M, Nadarajah N, Shimony S, Winer ES, Wadleigh M, Stone RM, DeAngelo DJ, Garcia JS, Haferlach T, Lindsley RC, Luskin MR, Stahl M, Tothova Z. Jann JC, et al. Among authors: tothova z. Leukemia. 2024 Sep;38(9):1992-2002. doi: 10.1038/s41375-024-02347-y. Epub 2024 Jul 20. Leukemia. 2024. PMID: 39033241 Free PMC article.
42 results