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Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis.
Liu XT, Huang Y, Liu D, Jiang YC, Zhao M, Chung LH, Han XD, Zhao Y, Chen J, Coleman P, Ting KK, Tran C, Su Y, Dennis CV, Bhatnagar A, Liu K, Don AS, Vadas MA, Gorrell MD, Zhang S, Murray M, Kavurma MM, McCaughan GW, Gamble JR, Qi Y. Liu XT, et al. Among authors: chung lh. J Transl Med. 2024 Jan 10;22(1):43. doi: 10.1186/s12967-023-04830-z. J Transl Med. 2024. PMID: 38200582 Free PMC article.
Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2.
Aji G, Huang Y, Ng ML, Wang W, Lan T, Li M, Li Y, Chen Q, Li R, Yan S, Tran C, Burchfield JG, Couttas TA, Chen J, Chung LH, Liu D, Wadham C, Hogg PJ, Gao X, Vadas MA, Gamble JR, Don AS, Xia P, Qi Y. Aji G, et al. Among authors: chung lh. Proc Natl Acad Sci U S A. 2020 Sep 29;117(39):24434-24442. doi: 10.1073/pnas.2007856117. Epub 2020 Sep 11. Proc Natl Acad Sci U S A. 2020. PMID: 32917816 Free PMC article.
Ablation of sphingosine kinase 2 suppresses fatty liver-associated hepatocellular carcinoma via downregulation of ceramide transfer protein.
Liu XT, Chung LH, Liu D, Chen J, Huang Y, Teo JD, Han XD, Zhao Y, Guan FHX, Tran C, Lee JY, Couttas TA, Liu K, McCaughan GW, Gorrell MD, Don AS, Zhang S, Qi Y. Liu XT, et al. Among authors: chung lh. Oncogenesis. 2022 Nov 4;11(1):67. doi: 10.1038/s41389-022-00444-0. Oncogenesis. 2022. PMID: 36333295 Free PMC article.
Deep serum lipidomics identifies evaluative and predictive biomarkers for individualized glycemic responses following low-energy diet-induced weight loss: a PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World (PREVIEW) substudy.
Jiang YC, Lai K, Muirhead RP, Chung LH, Huang Y, James E, Liu XT, Wu J, Atkinson FS, Yan S, Fogelholm M, Raben A, Don AS, Sun J, Brand-Miller JC, Qi Y. Jiang YC, et al. Among authors: chung lh. Am J Clin Nutr. 2024 Oct;120(4):864-878. doi: 10.1016/j.ajcnut.2024.08.015. Epub 2024 Aug 23. Am J Clin Nutr. 2024. PMID: 39182617
117 results