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Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis.
Liu XT, Huang Y, Liu D, Jiang YC, Zhao M, Chung LH, Han XD, Zhao Y, Chen J, Coleman P, Ting KK, Tran C, Su Y, Dennis CV, Bhatnagar A, Liu K, Don AS, Vadas MA, Gorrell MD, Zhang S, Murray M, Kavurma MM, McCaughan GW, Gamble JR, Qi Y. Liu XT, et al. Among authors: kavurma mm. J Transl Med. 2024 Jan 10;22(1):43. doi: 10.1186/s12967-023-04830-z. J Transl Med. 2024. PMID: 38200582 Free PMC article.
Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Promotes Angiogenesis and Ischemia-Induced Neovascularization Via NADPH Oxidase 4 (NOX4) and Nitric Oxide-Dependent Mechanisms.
Di Bartolo BA, Cartland SP, Prado-Lourenco L, Griffith TS, Gentile C, Ravindran J, Azahri NS, Thai T, Yeung AW, Thomas SR, Kavurma MM. Di Bartolo BA, et al. Among authors: kavurma mm. J Am Heart Assoc. 2015 Nov 16;4(11):e002527. doi: 10.1161/JAHA.115.002527. J Am Heart Assoc. 2015. PMID: 26572549 Free PMC article.
The generation of stable microvessels in ischemia is mediated by endothelial cell derived TRAIL.
Cartland SP, Patil MS, Kelland E, Le N, Boccanfuso L, Stanley CP, Cholan PM, Dona MI, Patrick R, McGrath J, Su QP, Alwis I, Ganss R, Powell JE, Harvey RP, Pinto AR, Griffith TS, Loa J, Aitken SJ, Robinson DA, Patel S, Kavurma MM. Cartland SP, et al. Among authors: kavurma mm. Sci Adv. 2024 Oct 4;10(40):eadn8760. doi: 10.1126/sciadv.adn8760. Epub 2024 Oct 4. Sci Adv. 2024. PMID: 39365855 Free PMC article.
57 results