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Five dominant dimensions of brain aging are identified via deep learning: associations with clinical, lifestyle, and genetic measures.
Yang Z, Wen J, Erus G, Govindarajan ST, Melhem R, Mamourian E, Cui Y, Srinivasan D, Abdulkadir A, Parmpi P, Wittfeld K, Grabe HJ, Bülow R, Frenzel S, Tosun D, Bilgel M, An Y, Yi D, Marcus DS, LaMontagne P, Benzinger TLS, Heckbert SR, Austin TR, Waldstein SR, Evans MK, Zonderman AB, Launer LJ, Sotiras A, Espeland MA, Masters CL, Maruff P, Fripp J, Toga A, O'Bryant S, Chakravarty MM, Villeneuve S, Johnson SC, Morris JC, Albert MS, Yaffe K, Völzke H, Ferrucci L, Bryan NR, Shinohara RT, Fan Y, Habes M, Lalousis PA, Koutsouleris N, Wolk DA, Resnick SM, Shou H, Nasrallah IM, Davatzikos C. Yang Z, et al. Among authors: nasrallah im. medRxiv [Preprint]. 2023 Dec 30:2023.12.29.23300642. doi: 10.1101/2023.12.29.23300642. medRxiv. 2023. PMID: 38234857 Free PMC article. Preprint.
MRI signatures of brain age and disease over the lifespan based on a deep brain network and 14 468 individuals worldwide.
Bashyam VM, Erus G, Doshi J, Habes M, Nasrallah I, Truelove-Hill M, Srinivasan D, Mamourian L, Pomponio R, Fan Y, Launer LJ, Masters CL, Maruff P, Zhuo C, Völzke H, Johnson SC, Fripp J, Koutsouleris N, Satterthwaite TD, Wolf D, Gur RE, Gur RC, Morris J, Albert MS, Grabe HJ, Resnick S, Bryan RN, Wolk DA, Shou H, Davatzikos C. Bashyam VM, et al. Brain. 2020 Jul 1;143(7):2312-2324. doi: 10.1093/brain/awaa160. Brain. 2020. PMID: 32591831 Free PMC article.
The Brain Chart of Aging: Machine-learning analytics reveals links between brain aging, white matter disease, amyloid burden, and cognition in the iSTAGING consortium of 10,216 harmonized MR scans.
Habes M, Pomponio R, Shou H, Doshi J, Mamourian E, Erus G, Nasrallah I, Launer LJ, Rashid T, Bilgel M, Fan Y, Toledo JB, Yaffe K, Sotiras A, Srinivasan D, Espeland M, Masters C, Maruff P, Fripp J, Völzk H, Johnson SC, Morris JC, Albert MS, Miller MI, Bryan RN, Grabe HJ, Resnick SM, Wolk DA, Davatzikos C; iSTAGING consortium, the Preclinical AD consortium, the ADNI, and the CARDIA studies. Habes M, et al. Alzheimers Dement. 2021 Jan;17(1):89-102. doi: 10.1002/alz.12178. Epub 2020 Sep 13. Alzheimers Dement. 2021. PMID: 32920988 Free PMC article.
Mid-life epigenetic age, neuroimaging brain age, and cognitive function: coronary artery risk development in young adults (CARDIA) study.
Zheng Y, Habes M, Gonzales M, Pomponio R, Nasrallah I, Khan S, Vaughan DE, Davatzikos C, Seshadri S, Launer L, Sorond F, Sedaghat S, Wainwright D, Baccarelli A, Sidney S, Bryan N, Greenland P, Lloyd-Jones D, Yaffe K, Hou L. Zheng Y, et al. Aging (Albany NY). 2022 Feb 27;14(4):1691-1712. doi: 10.18632/aging.203918. Epub 2022 Feb 27. Aging (Albany NY). 2022. PMID: 35220276 Free PMC article.
Nine Neuroimaging-AI Endophenotypes Unravel Disease Heterogeneity and Partial Overlap across Four Brain Disorders: A Dimensional Neuroanatomical Representation.
Wen J, Skampardoni I, Tian YE, Yang Z, Cui Y, Erus G, Hwang G, Varol E, Boquet-Pujadas A, Chand GB, Nasrallah I, Satterthwaite T, Shou H, Shen L, Toga AW, Zalesky A, Davatzikos C. Wen J, et al. medRxiv [Preprint]. 2024 Sep 25:2023.08.16.23294179. doi: 10.1101/2023.08.16.23294179. medRxiv. 2024. PMID: 37662256 Free PMC article. Preprint.
Sleep Duration and White Matter Quality in Middle-Aged Adults.
Yaffe K, Nasrallah I, Hoang TD, Lauderdale DS, Knutson KL, Carnethon MR, Launer LJ, Lewis CE, Sidney S. Yaffe K, et al. Sleep. 2016 Sep 1;39(9):1743-7. doi: 10.5665/sleep.6104. Sleep. 2016. PMID: 27397561 Free PMC article.
White matter microstructure, white matter lesions, and hypertension: An examination of early surrogate markers of vascular-related brain change in midlife.
Haight T, Nick Bryan R, Erus G, Hsieh MK, Davatzikos C, Nasrallah I, D'Esposito M, Jacobs DR Jr, Lewis C, Schreiner P, Sidney S, Meirelles O, Launer LJ. Haight T, et al. Neuroimage Clin. 2018 Mar 3;18:753-761. doi: 10.1016/j.nicl.2018.02.032. eCollection 2018. Neuroimage Clin. 2018. PMID: 29785359 Free PMC article.
111 results