The small inhibitor WM-1119 effectively targets KAT6A-rearranged AML, but not KMT2A-rearranged AML, despite shared KAT6 genetic dependency.
Sheridan M, Maqbool MA, Largeot A, Clayfield L, Xu J, Moncaut N, Sellers R, Whittle J, Paggetti J, Iqbal M, Aucagne R, Delva L, Baker SM, Lie-A-Ling M, Kouskoff V, Lacaud G.
Sheridan M, et al.
J Hematol Oncol. 2024 Oct 8;17(1):91. doi: 10.1186/s13045-024-01610-0.
J Hematol Oncol. 2024.
PMID: 39380002
Free PMC article.