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A synthetic agent ameliorates polycystic kidney disease by promoting apoptosis of cystic cells through increased oxidative stress.
Fedeles BI, Bhardwaj R, Ishikawa Y, Khumsubdee S, Krappitz M, Gubina N, Volpe I, Andrade DC, Westergerling P, Staudner T, Campolo J, Liu SS, Dong K, Cai Y, Rehman M, Gallagher AR, Ruchirawat S, Croy RG, Essigmann JM, Fedeles SV, Somlo S. Fedeles BI, et al. Among authors: essigmann jm. Proc Natl Acad Sci U S A. 2024 Jan 23;121(4):e2317344121. doi: 10.1073/pnas.2317344121. Epub 2024 Jan 19. Proc Natl Acad Sci U S A. 2024. PMID: 38241440 Free PMC article.
Molecular origins of mutational spectra produced by the environmental carcinogen N-nitrosodimethylamine and SN1 chemotherapeutic agents.
Armijo AL, Thongararm P, Fedeles BI, Yau J, Kay JE, Corrigan JJ, Chancharoen M, Chawanthayatham S, Samson LD, Carrasco SE, Engelward BP, Fox JG, Croy RG, Essigmann JM. Armijo AL, et al. Among authors: essigmann jm. NAR Cancer. 2023 Mar 27;5(2):zcad015. doi: 10.1093/narcan/zcad015. eCollection 2023 Jun. NAR Cancer. 2023. PMID: 36992846 Free PMC article.
7,8-Dihydro-8-oxo-1,N6-ethenoadenine: an exclusively Hoogsteen-paired thymine mimic in DNA that induces A→T transversions in Escherichia coli.
Aralov AV, Gubina N, Cabrero C, Tsvetkov VB, Turaev AV, Fedeles BI, Croy RG, Isaakova EA, Melnik D, Dukova S, Ryazantsev DY, Khrulev AA, Varizhuk AM, González C, Zatsepin TS, Essigmann JM. Aralov AV, et al. Among authors: essigmann jm. Nucleic Acids Res. 2022 Apr 8;50(6):3056-3069. doi: 10.1093/nar/gkac148. Nucleic Acids Res. 2022. PMID: 35234900 Free PMC article.
Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice.
Kay JE, Corrigan JJ, Armijo AL, Nazari IS, Kohale IN, Torous DK, Avlasevich SL, Croy RG, Wadduwage DN, Carrasco SE, Dertinger SD, White FM, Essigmann JM, Samson LD, Engelward BP. Kay JE, et al. Among authors: essigmann jm. Cell Rep. 2021 Mar 16;34(11):108864. doi: 10.1016/j.celrep.2021.108864. Cell Rep. 2021. PMID: 33730582 Free PMC article.
174 results