Pagire SH - Search Results

1

Inhibition of HTR2B-mediated serotonin signaling in colorectal cancer suppresses tumor growth through ERK signaling.

Lee JY, Park S, Park EJ, Pagire HS, Pagire SH, Choi BW, Park M, Fang S, Ahn JH, Oh CM. Lee JY, et al. Among authors: pagire sh. Biomed Pharmacother. 2024 Oct;179:117428. doi: 10.1016/j.biopha.2024.117428. Epub 2024 Sep 9. Biomed Pharmacother. 2024. PMID: 39255737 Free article.

2

PDK4-mediated metabolic reprogramming is a potential therapeutic target for neovascular age-related macular degeneration.

Kim J, Jeon Y, Son J, Pagire HS, Pagire SH, Ahn JH, Uemura A, Lee IK, Park S, Park DH. Kim J, et al. Among authors: pagire sh. Cell Death Dis. 2024 Aug 9;15(8):582. doi: 10.1038/s41419-024-06968-0. Cell Death Dis. 2024. PMID: 39122684 Free PMC article.

3

Activation mechanism and novel binding sites of the BK_Ca channel activator CTIBD.

Lee N, Kim S, Lee NY, Jo H, Jeong P, Pagire HS, Pagire SH, Ahn JH, Jin MS, Park CS. Lee N, et al. Among authors: pagire sh. Life Sci Alliance. 2024 Aug 1;7(10):e202402621. doi: 10.26508/lsa.202402621. Print 2024 Oct. Life Sci Alliance. 2024. PMID: 39089879 Free PMC article.

4

Discovery of a peripheral 5HT_2A antagonist as a clinical candidate for metabolic dysfunction-associated steatohepatitis.

Pagire HS, Pagire SH, Jeong BK, Choi WI, Oh CJ, Lim CW, Kim M, Yoon J, Kim SS, Bae MA, Jeon JH, Song S, Lee HJ, Lee EY, Goughnour PC, Kim D, Lee IK, Loomba R, Kim H, Ahn JH. Pagire HS, et al. Among authors: pagire sh. Nat Commun. 2024 Jan 20;15(1):645. doi: 10.1038/s41467-024-44874-3. Nat Commun. 2024. PMID: 38245505 Free PMC article.

5

Inhibition of pyruvate dehydrogenase kinase 4 ameliorates kidney ischemia-reperfusion injury by reducing succinate accumulation during ischemia and preserving mitochondrial function during reperfusion.

Oh CJ, Kim MJ, Lee JM, Kim DH, Kim IY, Park S, Kim Y, Lee KB, Lee SH, Lim CW, Kim M, Lee JY, Pagire HS, Pagire SH, Bae MA, Chanda D, Thoudam T, Khang AR, Harris RA, Ahn JH, Jeon JH, Lee IK. Oh CJ, et al. Among authors: pagire sh. Kidney Int. 2023 Oct;104(4):724-739. doi: 10.1016/j.kint.2023.06.022. Epub 2023 Jul 1. Kidney Int. 2023. PMID: 37399974

6

Inhibition of Pyruvate Dehydrogenase Kinase 4 in CD4⁺ T Cells Ameliorates Intestinal Inflammation.

Lee H, Jeon JH, Lee YJ, Kim MJ, Kwon WH, Chanda D, Thoudam T, Pagire HS, Pagire SH, Ahn JH, Harris RA, Kim ES, Lee IK. Lee H, et al. Among authors: pagire sh. Cell Mol Gastroenterol Hepatol. 2023;15(2):439-461. doi: 10.1016/j.jcmgh.2022.09.016. Epub 2022 Oct 10. Cell Mol Gastroenterol Hepatol. 2023. PMID: 36229019 Free PMC article.

7

Synthesis and biological evaluation of tyrosine derivatives as peripheral 5HT_2A receptor antagonists for nonalcoholic fatty liver disease.

Kim M, Choi W, Yoon J, Jeong BK, Pagire SH, Pagire HS, Park J, Nam JE, Oh CJ, Jeon JH, Kim SS, Lee BH, Song JS, Bae MA, Lee IK, Kim H, Ahn JH. Kim M, et al. Among authors: pagire sh. Eur J Med Chem. 2022 Sep 5;239:114517. doi: 10.1016/j.ejmech.2022.114517. Epub 2022 Jun 15. Eur J Med Chem. 2022. PMID: 35732081

8

Identification of New Non-BBB Permeable Tryptophan Hydroxylase Inhibitors for Treating Obesity and Fatty Liver Disease.

Pagire SH, Pagire HS, Park KY, Bae EJ, Kim KE, Kim M, Yoon J, Parameswaran S, Choi JH, Park S, Jeon JH, Song JS, Bae MA, Lee IK, Kim H, Suh JM, Ahn JH. Pagire SH, et al. Molecules. 2022 May 25;27(11):3417. doi: 10.3390/molecules27113417. Molecules. 2022. PMID: 35684355 Free PMC article.

9

Peripheral Selective Oxadiazolylphenyl Alanine Derivatives as Tryptophan Hydroxylase 1 Inhibitors for Obesity and Fatty Liver Disease.

Bae EJ, Choi WG, Pagire HS, Pagire SH, Parameswaran S, Choi JH, Yoon J, Choi WI, Lee JH, Song JS, Bae MA, Kim M, Jeon JH, Lee IK, Kim H, Ahn JH. Bae EJ, et al. Among authors: pagire sh. J Med Chem. 2021 Jan 28;64(2):1037-1053. doi: 10.1021/acs.jmedchem.0c01560. Epub 2021 Jan 8. J Med Chem. 2021. PMID: 33417443

10

Identification and Characterization of a Novel Large-Conductance Calcium-Activated Potassium Channel Activator, CTIBD, and Its Relaxation Effect on Urinary Bladder Smooth Muscle.

Lee N, Lim BH, Lee KS, Shin J, Pagire HS, Pagire SH, Ahn JH, Lee SW, Kang TM, Park CS. Lee N, et al. Among authors: pagire sh. Mol Pharmacol. 2021 Feb;99(2):114-124. doi: 10.1124/molpharm.120.000106. Epub 2020 Dec 2. Mol Pharmacol. 2021. PMID: 33268552

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