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Eganelisib combined with immune checkpoint inhibitor therapy and chemotherapy in frontline metastatic triple-negative breast cancer triggers macrophage reprogramming, immune activation and extracellular matrix reorganization in the tumor microenvironment.
O'Connell BC, Hubbard C, Zizlsperger N, Fitzgerald D, Kutok JL, Varner J, Ilaria R Jr, Cobleigh MA, Juric D, Tkaczuk KHR, Elias A, Lee A, Dakhil S, Hamilton E, Soliman H, Peluso S. O'Connell BC, et al. J Immunother Cancer. 2024 Aug 30;12(8):e009160. doi: 10.1136/jitc-2024-009160. J Immunother Cancer. 2024. PMID: 39214650 Free PMC article. Clinical Trial.
PI3Kγ inhibition circumvents inflammation and vascular leak in SARS-CoV-2 and other infections.
Shepard RM, Ghebremedhin A, Pratumchai I, Robinson SR, Betts C, Hu J, Sasik R, Fisch KM, Zak J, Chen H, Paradise M, Rivera J, Amjad M, Uchiyama S, Seo H, Campos AD, Dayao DA, Tzipori S, Piedra-Mora C, Das S, Hasteh F, Russo H, Sun X, Xu L, E Alexander LC, Duran JM, Odish M, Pretorius V, Kirchberger NC, Chin SM, Von Schalscha T, Cheresh D, Morrey JD, Alargova R, O'Connell B, Martinot TA, Patel SP, Nizet V, Martinot AJ, Coussens LM, Teijaro JR, Varner JA. Shepard RM, et al. Among authors: varner ja. Sci Transl Med. 2024 Jul 3;16(754):eadi6887. doi: 10.1126/scitranslmed.adi6887. Epub 2024 Jul 3. Sci Transl Med. 2024. PMID: 38959328 Free PMC article.
JAK inhibition enhances checkpoint blockade immunotherapy in patients with Hodgkin lymphoma.
Zak J, Pratumchai I, Marro BS, Marquardt KL, Zavareh RB, Lairson LL, Oldstone MBA, Varner JA, Hegerova L, Cao Q, Farooq U, Kenkre VP, Bachanova V, Teijaro JR. Zak J, et al. Among authors: varner ja. Science. 2024 Jun 21;384(6702):eade8520. doi: 10.1126/science.ade8520. Epub 2024 Jun 21. Science. 2024. PMID: 38900864 Clinical Trial.
PI3Kγ inhibition combined with DNA vaccination unleashes a B-cell-dependent antitumor immunity that hampers pancreatic cancer.
Curcio C, Mucciolo G, Roux C, Brugiapaglia S, Scagliotti A, Guadagnin G, Conti L, Longo D, Grosso D, Papotti MG, Hirsch E, Cappello P, Varner JA, Novelli F. Curcio C, et al. Among authors: varner ja. J Exp Clin Cancer Res. 2024 Jun 1;43(1):157. doi: 10.1186/s13046-024-03080-1. J Exp Clin Cancer Res. 2024. PMID: 38824552 Free PMC article.
Enzyme lights dual fires to promote cancer.
Ghebremedhin A, Varner JA. Ghebremedhin A, et al. Among authors: varner ja. Nature. 2023 May;617(7959):42-43. doi: 10.1038/d41586-023-01025-w. Nature. 2023. PMID: 37076711 No abstract available.
75 results