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Investigation of morpholine isosters for the development of a potent, selective and metabolically stable mTOR kinase inhibitor.
De Pascale M, Bissegger L, Tarantelli C, Beaufils F, Prescimone A, Mohamed Seid Hedad H, Kayali O, Orbegozo C, Raguž L, Schaefer T, Hebeisen P, Bertoni F, Wymann MP, Borsari C. De Pascale M, et al. Among authors: wymann mp. Eur J Med Chem. 2023 Feb 15;248:115038. doi: 10.1016/j.ejmech.2022.115038. Epub 2022 Dec 28. Eur J Med Chem. 2023. PMID: 36634458 Free article.
Nuclear and cytosolic fractions of SOX2 synergize as transcriptional and translational co-regulators of cell fate.
Schaefer T, Mittal N, Wang H, Ataman M, Candido S, Lötscher J, Velychko S, Tintignac L, Bock T, Börsch A, Baßler J, Rao TN, Zmajkovic J, Roffeis S, Löliger J, Jacob F, Dumlin A, Schürch C, Schmidt A, Skoda RC, Wymann MP, Hess C, Schöler HR, Zaehres H, Hurt E, Zavolan M, Lengerke C. Schaefer T, et al. Among authors: wymann mp. Cell Rep. 2024 Oct 22;43(10):114807. doi: 10.1016/j.celrep.2024.114807. Epub 2024 Oct 3. Cell Rep. 2024. PMID: 39368083 Free article.
Rapid, potent, and persistent covalent chemical probes to deconvolute PI3Kα signaling.
Bissegger L, Constantin TA, Keles E, Raguž L, Barlow-Busch I, Orbegozo C, Schaefer T, Borlandelli V, Bohnacker T, Sriramaratnam R, Schäfer A, Gstaiger M, Burke JE, Borsari C, Wymann MP. Bissegger L, et al. Among authors: wymann mp. Chem Sci. 2024 Nov 12. doi: 10.1039/d4sc05459h. Online ahead of print. Chem Sci. 2024. PMID: 39568927 Free PMC article.
Specific Requirement of the p84/p110γ Complex of PI3Kγ for Antibody-Activated, Inducible Cross-Presentation in Murine Type 2 DCs.
Koumantou D, Adiko AC, Bourdely P, Nugue M, Boedec E, El-Benna J, Monteiro R, Saveanu C, Laffargue M, Wymann MP, Dalod M, Guermonprez P, Saveanu L. Koumantou D, et al. Among authors: wymann mp. Adv Sci (Weinh). 2024 Nov;11(44):e2401179. doi: 10.1002/advs.202401179. Epub 2024 Oct 9. Adv Sci (Weinh). 2024. PMID: 39382167 Free PMC article.
PI3Kγ in B cells promotes antibody responses and generation of antibody-secreting cells.
Lanahan SM, Yang L, Jones KM, Qi Z, Cabrera EC, Cominsky LY, Ramaswamy A, Barmada A, Gabernet G, Uthaya Kumar DB, Xu L, Shan P, Wymann MP, Kleinstein SH, Rao VK, Mustillo P, Romberg N, Abraham RS, Lucas CL. Lanahan SM, et al. Among authors: wymann mp. Nat Immunol. 2024 Aug;25(8):1422-1431. doi: 10.1038/s41590-024-01890-1. Epub 2024 Jul 3. Nat Immunol. 2024. PMID: 38961274
A combined cross-sectional analysis and case-control study evaluating tick-borne encephalitis vaccination coverage, disease and vaccine effectiveness in children and adolescents, Switzerland, 2005 to 2022.
Zens KD, Altpeter E, Wymann MN, Mack A, Baer NB, Haile SR, Steffen R, Fehr JS, Lang P. Zens KD, et al. Among authors: wymann mn. Euro Surveill. 2024 May;29(18):2300558. doi: 10.2807/1560-7917.ES.2024.29.18.2300558. Euro Surveill. 2024. PMID: 38699900 Free PMC article.
Legionnaires' disease in Switzerland: rationale and study protocol of a prospective national case-control and molecular source attribution study (SwissLEGIO).
Fischer FB, Bigler M, Mäusezahl D, Hattendorf J, Egli A, Julian TR, Rölli F, Gaia V, Wymann M, Fridez F, Bertschi S; SwissLEGIO Hospital Network. Fischer FB, et al. Among authors: wymann m. Infection. 2023 Oct;51(5):1467-1479. doi: 10.1007/s15010-023-02014-x. Epub 2023 Mar 11. Infection. 2023. PMID: 36905400 Free PMC article.
147 results