Leavitt BR - Search Results

1

Safety and efficacy of laquinimod for Huntington's disease (LEGATO-HD): a multicentre, randomised, double-blind, placebo-controlled, phase 2 study.

Reilmann R, Anderson KE, Feigin A, Tabrizi SJ, Leavitt BR, Stout JC, Piccini P, Schubert R, Loupe P, Wickenberg A, Borowsky B, Rynkowski G, Volkinshtein R, Li T, Savola JM, Hayden M, Gordon MF; LEGATO-HD Study Group. Reilmann R, et al. Among authors: leavitt br. Lancet Neurol. 2024 Mar;23(3):243-255. doi: 10.1016/S1474-4422(23)00454-4. Epub 2024 Jan 24. Lancet Neurol. 2024. PMID: 38280392 Clinical Trial.

2

Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease.

Zeron MM, Hansson O, Chen N, Wellington CL, Leavitt BR, Brundin P, Hayden MR, Raymond LA. Zeron MM, et al. Among authors: leavitt br. Neuron. 2002 Mar 14;33(6):849-60. doi: 10.1016/s0896-6273(02)00615-3. Neuron. 2002. PMID: 11906693 Free article.

3

Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease.

Li L, Fan M, Icton CD, Chen N, Leavitt BR, Hayden MR, Murphy TH, Raymond LA. Li L, et al. Among authors: leavitt br. Neurobiol Aging. 2003 Dec;24(8):1113-21. doi: 10.1016/j.neurobiolaging.2003.04.003. Neurobiol Aging. 2003. PMID: 14643383

4

Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease.

Zeron MM, Fernandes HB, Krebs C, Shehadeh J, Wellington CL, Leavitt BR, Baimbridge KG, Hayden MR, Raymond LA. Zeron MM, et al. Among authors: leavitt br. Mol Cell Neurosci. 2004 Mar;25(3):469-79. doi: 10.1016/j.mcn.2003.11.014. Mol Cell Neurosci. 2004. PMID: 15033175

5

Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease.

Van Raamsdonk JM, Pearson J, Rogers DA, Bissada N, Vogl AW, Hayden MR, Leavitt BR. Van Raamsdonk JM, et al. Among authors: leavitt br. Hum Mol Genet. 2005 May 15;14(10):1379-92. doi: 10.1093/hmg/ddi147. Epub 2005 Apr 13. Hum Mol Genet. 2005. PMID: 15829505

6

Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington's disease.

Van Raamsdonk JM, Pearson J, Slow EJ, Hossain SM, Leavitt BR, Hayden MR. Van Raamsdonk JM, et al. Among authors: leavitt br. J Neurosci. 2005 Apr 20;25(16):4169-80. doi: 10.1523/JNEUROSCI.0590-05.2005. J Neurosci. 2005. PMID: 15843620 Free PMC article.

7

Ethyl-EPA treatment improves motor dysfunction, but not neurodegeneration in the YAC128 mouse model of Huntington disease.

Van Raamsdonk JM, Pearson J, Rogers DA, Lu G, Barakauskas VE, Barr AM, Honer WG, Hayden MR, Leavitt BR. Van Raamsdonk JM, et al. Among authors: leavitt br. Exp Neurol. 2005 Dec;196(2):266-72. doi: 10.1016/j.expneurol.2005.07.021. Epub 2005 Aug 29. Exp Neurol. 2005. PMID: 16129433

8

Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease.

Shehadeh J, Fernandes HB, Zeron Mullins MM, Graham RK, Leavitt BR, Hayden MR, Raymond LA. Shehadeh J, et al. Among authors: leavitt br. Neurobiol Dis. 2006 Feb;21(2):392-403. doi: 10.1016/j.nbd.2005.08.001. Epub 2005 Sep 13. Neurobiol Dis. 2006. PMID: 16165367

9

Cystamine treatment is neuroprotective in the YAC128 mouse model of Huntington disease.

Van Raamsdonk JM, Pearson J, Bailey CD, Rogers DA, Johnson GV, Hayden MR, Leavitt BR. Van Raamsdonk JM, et al. Among authors: leavitt br. J Neurochem. 2005 Oct;95(1):210-20. doi: 10.1111/j.1471-4159.2005.03357.x. J Neurochem. 2005. PMID: 16181425 Free article.

10

Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models.

Graham RK, Slow EJ, Deng Y, Bissada N, Lu G, Pearson J, Shehadeh J, Leavitt BR, Raymond LA, Hayden MR. Graham RK, et al. Among authors: leavitt br. Neurobiol Dis. 2006 Feb;21(2):444-55. doi: 10.1016/j.nbd.2005.08.007. Epub 2005 Oct 17. Neurobiol Dis. 2006. PMID: 16230019

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