Kwak J - Search Results

1

Amelioration of Astrocyte-Mediated Neuroinflammation by EI-16004 Confers Neuroprotection in an MPTP-induced Parkinson's Disease Model.

Kim J, Lee S, Hong DG, Yang S, Tran CS, Kwak J, Kim MJ, Rajarathinam T, Chung KW, Jung YS, Ishigami A, Chang SC, Lee H, Yun H, Lee J. Kim J, et al. Among authors: kwak j. Neuromolecular Med. 2024 Jan 30;26(1):1. doi: 10.1007/s12017-023-08769-8. Neuromolecular Med. 2024. PMID: 38294608

2

Pharmacokinetic Evaluation of Metabolic Drug Interactions between Repaglinide and Celecoxib by a Bioanalytical HPLC Method for Their Simultaneous Determination with Fluorescence Detection.

Han DG, Kwak J, Seo SW, Kim JM, Yoo JW, Jung Y, Lee YH, Kim MS, Jung YS, Yun H, Yoon IS. Han DG, et al. Among authors: kwak j. Pharmaceutics. 2019 Aug 2;11(8):382. doi: 10.3390/pharmaceutics11080382. Pharmaceutics. 2019. PMID: 31382371 Free PMC article.

3

Discovery and SAR studies of 3-amino-4-(phenylsulfonyl)tetrahydrothiophene 1,1-dioxides as non-electrophilic antioxidant response element (ARE) activators.

Jo J, Ibrahim L, Iaconelli J, Kwak J, Kumar M, Jung Y, Lairson LL, Chatterjee AK, Schultz PG, Bollong MJ, Yun H. Jo J, et al. Among authors: kwak j. Bioorg Chem. 2021 Mar;108:104614. doi: 10.1016/j.bioorg.2020.104614. Epub 2021 Jan 5. Bioorg Chem. 2021. PMID: 33508678

4

Discovery and optimization of novel 3-benzyl-N-phenyl-1H-pyrazole-5-carboxamides as bifunctional antidiabetic agents stimulating both insulin secretion and glucose uptake.

Jo J, Lee D, Park YH, Choi H, Han J, Park DH, Choi YK, Kwak J, Yang MK, Yoo JW, Moon HR, Geum D, Kang KS, Yun H. Jo J, et al. Among authors: kwak j. Eur J Med Chem. 2021 May 5;217:113325. doi: 10.1016/j.ejmech.2021.113325. Epub 2021 Mar 6. Eur J Med Chem. 2021. PMID: 33765605

5

A bioisosteric approach to the discovery of novel N-aryl-N'-[4-(aryloxy)cyclohexyl]squaramide-based activators of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation.

Kwak J, Kim MJ, Kim S, Park GB, Jo J, Jeong M, Kang S, Moon S, Bang S, An H, Hwang S, Kim MS, Yoo JW, Moon HR, Chang W, Chung KW, Jeong JY, Yun H. Kwak J, et al. Eur J Med Chem. 2022 Sep 5;239:114501. doi: 10.1016/j.ejmech.2022.114501. Epub 2022 May 29. Eur J Med Chem. 2022. PMID: 35716517

6

Physicochemical characterization and phase II metabolic profiling of echinochrome A, a bioactive constituent from sea urchin, and its physiologically based pharmacokinetic modeling in rats and humans.

Han DG, Kwak J, Choi E, Seo SW, Vasileva EA, Mishchenko NP, Fedoreyev SA, Stonik VA, Kim HK, Han J, Byun JH, Jung IH, Yun H, Yoon IS. Han DG, et al. Among authors: kwak j. Biomed Pharmacother. 2023 Jun;162:114589. doi: 10.1016/j.biopha.2023.114589. Epub 2023 Mar 31. Biomed Pharmacother. 2023. PMID: 37004327 Free article. Clinical Trial.

7

Discovery of N-Aryl-N'-[4-(aryloxy)cyclohexyl]squaramide-Based Inhibitors of LXR/SREBP-1c Signaling Pathway Ameliorating Steatotic Liver Disease: Navigating the Role of SIRT6 Activation.

Nguyen LH, Cho YE, Kim S, Kim Y, Kwak J, Suh JS, Lee J, Son K, Kim M, Jang ES, Song N, Choi B, Kim J, Tak Y, Hwang T, Jo J, Lee EW, Kim SB, Kim S, Kwon OB, Kim S, Lee SR, Lee H, Kim TJ, Hwang S, Yun H. Nguyen LH, et al. Among authors: kwak j. J Med Chem. 2024 Oct 10;67(19):17608-17628. doi: 10.1021/acs.jmedchem.4c01597. Epub 2024 Sep 11. J Med Chem. 2024. PMID: 39259827

8

Discovery of 2-aryloxy-4-amino-quinazoline derivatives as novel protease-activated receptor 2 (PAR2) antagonists.

Cho NC, Cha JH, Kim H, Kwak J, Kim D, Seo SH, Shin JS, Kim T, Park KD, Lee J, No KT, Kim YK, Lee KT, Pae AN. Cho NC, et al. Among authors: kwak j. Bioorg Med Chem. 2015 Dec 15;23(24):7717-27. doi: 10.1016/j.bmc.2015.11.016. Epub 2015 Nov 18. Bioorg Med Chem. 2015. PMID: 26631441

9

Discovery and biological evaluation of tetrahydrothieno[2,3-c]pyridine derivatives as selective metabotropic glutamate receptor 1 antagonists for the potential treatment of neuropathic pain.

Nam M, Kim T, Kwak J, Seo SH, Ko MK, Lim EJ, Min SJ, Cho YS, Keum G, Baek DJ, Lee J, Pae AN. Nam M, et al. Among authors: kwak j. Eur J Med Chem. 2015 Jun 5;97:245-58. doi: 10.1016/j.ejmech.2015.04.060. Epub 2015 Apr 30. Eur J Med Chem. 2015. PMID: 25984841

10

The CT collateral map: collateral perfusion estimation and baseline lesion assessment after acute anterior circulation ischemic stroke.

Ki HJ, Roh HG, Kwak JT, Kim IS, Park JJ, Jeon YS, Yang H, Jung S, Lee JS, Kim HJ. Ki HJ, et al. Among authors: kwak jt. Radiol Med. 2024 Dec 11. doi: 10.1007/s11547-024-01941-5. Online ahead of print. Radiol Med. 2024. PMID: 39661247

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