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Discovery and Preclinical Pharmacology of NX-2127, an Orally Bioavailable Degrader of Bruton's Tyrosine Kinase with Immunomodulatory Activity for the Treatment of Patients with B Cell Malignancies.
Robbins DW, Noviski MA, Tan YS, Konst ZA, Kelly A, Auger P, Brathaban N, Cass R, Chan ML, Cherala G, Clifton MC, Gajewski S, Ingallinera TG, Karr D, Kato D, Ma J, McKinnell J, McIntosh J, Mihalic J, Murphy B, Panga JR, Peng G, Powers J, Perez L, Rountree R, Tenn-McClellan A, Sands AT, Weiss DR, Wu J, Ye J, Guiducci C, Hansen G, Cohen F. Robbins DW, et al. Among authors: tan ys. J Med Chem. 2024 Feb 22;67(4):2321-2336. doi: 10.1021/acs.jmedchem.3c01007. Epub 2024 Feb 1. J Med Chem. 2024. PMID: 38300987
NRX-0492 degrades wild-type and C481 mutant BTK and demonstrates in vivo activity in CLL patient-derived xenografts.
Zhang D, Harris HM, Chen J, Judy J, James G, Kelly A, McIntosh J, Tenn-McClellan A, Ambing E, Tan YS, Lu H, Gajewski S, Clifton MC, Yung S, Robbins DW, Pirooznia M, Skånland SS, Gaglione E, Mhibik M, Underbayev C, Ahn IE, Sun C, Herman SEM, Noviski M, Wiestner A. Zhang D, et al. Among authors: tan ys. Blood. 2023 Mar 30;141(13):1584-1596. doi: 10.1182/blood.2022016934. Blood. 2023. PMID: 36375120 Free PMC article.
SUMOylation of Warts kinase promotes neural stem cell reactivation.
Gao Y, Tan YS, Lin J, Chew LY, Aung HY, Palliyana B, Gujar MR, Lin KY, Kondo S, Wang H. Gao Y, et al. Among authors: tan ys. Nat Commun. 2024 Oct 17;15(1):8557. doi: 10.1038/s41467-024-52569-y. Nat Commun. 2024. PMID: 39419973 Free PMC article.
Innovative strategies for characterizing and managing huanglongbing in citrus.
Mubeen M, Ali A, Iftikhar Y, Shahbaz M, Ullah MI, Ali MA, Fatima N, Sathiya Seelan JS, Tan YS, Algopishi UB. Mubeen M, et al. Among authors: tan ys. World J Microbiol Biotechnol. 2024 Oct 8;40(11):342. doi: 10.1007/s11274-024-04135-3. World J Microbiol Biotechnol. 2024. PMID: 39375239 Review.
338 results