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A Gamma-adapted subunit vaccine induces broadly neutralizing antibodies against SARS-CoV-2 variants and protects mice from infection.
Coria LM, Rodriguez JM, Demaria A, Bruno LA, Medrano MR, Castro CP, Castro EF, Del Priore SA, Hernando Insua AC, Kaufmann IG, Saposnik LM, Stone WB, Prado L, Notaro US, Amweg AN, Diaz PU, Avaro M, Ortega H, Ceballos A, Krum V, Zurvarra FM, Sidabra JE, Drehe I, Baqué JA, Li Causi M, De Nichilo AV, Payes CJ, Southard T, Vega JC, Auguste AJ, Álvarez DE, Flo JM, Pasquevich KA, Cassataro J. Coria LM, et al. Nat Commun. 2024 Feb 2;15(1):997. doi: 10.1038/s41467-024-45180-8. Nat Commun. 2024. PMID: 38307851 Free PMC article.
A Novel Bacterial Protease Inhibitor Adjuvant in RBD-Based COVID-19 Vaccine Formulations Containing Alum Increases Neutralizing Antibodies, Specific Germinal Center B Cells and Confers Protection Against SARS-CoV-2 Infection in Mice.
Coria LM, Saposnik LM, Pueblas Castro C, Castro EF, Bruno LA, Stone WB, Pérez PS, Darriba ML, Chemes LB, Alcain J, Mazzitelli I, Varese A, Salvatori M, Auguste AJ, Álvarez DE, Pasquevich KA, Cassataro J. Coria LM, et al. Front Immunol. 2022 Feb 28;13:844837. doi: 10.3389/fimmu.2022.844837. eCollection 2022. Front Immunol. 2022. PMID: 35296091 Free PMC article.
Safety and immunogenicity of a SARS-CoV-2 Gamma variant RBD-based protein adjuvanted vaccine used as booster in healthy adults.
Pasquevich KA, Coria LM, Ceballos A, Mazzitelli B, Rodriguez JM, Demaría A, Pueblas Castro C, Bruno L, Saposnik L, Salvatori M, Varese A, González S, González Martínez VV, Geffner J, Álvarez D; Laboratorio Pablo Cassará R&D and CMC for ARVAC CG consortium; Feleder E, Halabe K, Perez Lera PE, de Oca FM, Vega JC, Lombardo M, Yerino GA, Fló J, Cassataro J. Pasquevich KA, et al. Among authors: coria lm. Nat Commun. 2023 Jul 28;14(1):4551. doi: 10.1038/s41467-023-40272-3. Nat Commun. 2023. PMID: 37507392 Free PMC article. Clinical Trial.
An oral vaccine based on U-Omp19 induces protection against B. abortus mucosal challenge by inducing an adaptive IL-17 immune response in mice.
Pasquevich KA, Ibañez AE, Coria LM, García Samartino C, Estein SM, Zwerdling A, Barrionuevo P, Oliveira FS, Seither C, Warzecha H, Oliveira SC, Giambartolomei GH, Cassataro J. Pasquevich KA, et al. Among authors: coria lm. PLoS One. 2011 Jan 14;6(1):e16203. doi: 10.1371/journal.pone.0016203. PLoS One. 2011. PMID: 21264260 Free PMC article.
A disordered region retains the full protease inhibitor activity and the capacity to induce CD8+ T cells in vivo of the oral vaccine adjuvant U-Omp19.
Laura Darriba M, Castro CP, Coria LM, Bruno L, Laura Cerutti M, Otero LH, Chemes LB, Rasia RM, Klinke S, Cassataro J, Pasquevich KA. Laura Darriba M, et al. Among authors: coria lm. Comput Struct Biotechnol J. 2022 Sep 6;20:5098-5114. doi: 10.1016/j.csbj.2022.08.054. eCollection 2022. Comput Struct Biotechnol J. 2022. PMID: 36187929 Free PMC article.
Immunization with recombinant Brucella species outer membrane protein Omp16 or Omp19 in adjuvant induces specific CD4+ and CD8+ T cells as well as systemic and oral protection against Brucella abortus infection.
Pasquevich KA, Estein SM, García Samartino C, Zwerdling A, Coria LM, Barrionuevo P, Fossati CA, Giambartolomei GH, Cassataro J. Pasquevich KA, et al. Among authors: coria lm. Infect Immun. 2009 Jan;77(1):436-45. doi: 10.1128/IAI.01151-08. Epub 2008 Nov 3. Infect Immun. 2009. PMID: 18981242 Free PMC article.
22 results