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Page 1
Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results.
Crespo-Garcia S, Fournier F, Diaz-Marin R, Klier S, Ragusa D, Masaki L, Cagnone G, Blot G, Hafiane I, Dejda A, Rizk R, Juneau R, Buscarlet M, Chorfi S, Patel P, Beltran PJ, Joyal JS, Rezende FA, Hata M, Nguyen A, Sullivan L, Damiano J, Wilson AM, Mallette FA, David NE, Ghosh A, Tsuruda PR, Dananberg J, Sapieha P. Crespo-Garcia S, et al. Among authors: diaz marin r. Nat Med. 2024 Feb;30(2):443-454. doi: 10.1038/s41591-024-02802-4. Epub 2024 Feb 6. Nat Med. 2024. PMID: 38321220 Clinical Trial.
HIF1α-dependent hypoxia response in myeloid cells requires IRE1α.
Mawambo G, Oubaha M, Ichiyama Y, Blot G, Crespo-Garcia S, Dejda A, Binet F, Diaz-Marin R, Sawchyn C, Sergeev M, Juneau R, Kaufman RJ, Affar EB, Mallette FA, Wilson AM, Sapieha P. Mawambo G, et al. Among authors: diaz marin r. J Neuroinflammation. 2023 Jun 21;20(1):145. doi: 10.1186/s12974-023-02793-y. J Neuroinflammation. 2023. PMID: 37344842 Free PMC article.
Early-life peripheral infections reprogram retinal microglia and aggravate neovascular age-related macular degeneration in later life.
Hata M, Hata M, Andriessen EM, Juneau R, Pilon F, Crespo-Garcia S, Diaz-Marin R, Guber V, Binet F, Fournier F, Buscarlet M, Grou C, Calderon V, Heckel E, Melichar HJ, Joyal JS, Wilson AM, Sapieha P. Hata M, et al. Among authors: diaz marin r. J Clin Invest. 2023 Feb 15;133(4):e159757. doi: 10.1172/JCI159757. J Clin Invest. 2023. PMID: 36787231 Free PMC article.
Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation.
Hata M, Andriessen EMMA, Hata M, Diaz-Marin R, Fournier F, Crespo-Garcia S, Blot G, Juneau R, Pilon F, Dejda A, Guber V, Heckel E, Daneault C, Calderon V, Des Rosiers C, Melichar HJ, Langmann T, Joyal JS, Wilson AM, Sapieha P. Hata M, et al. Among authors: diaz marin r. Science. 2023 Jan 6;379(6627):45-62. doi: 10.1126/science.abj8894. Epub 2023 Jan 5. Science. 2023. PMID: 36603072
Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy.
Binet F, Cagnone G, Crespo-Garcia S, Hata M, Neault M, Dejda A, Wilson AM, Buscarlet M, Mawambo GT, Howard JP, Diaz-Marin R, Parinot C, Guber V, Pilon F, Juneau R, Laflamme R, Sawchyn C, Boulay K, Leclerc S, Abu-Thuraia A, Côté JF, Andelfinger G, Rezende FA, Sennlaub F, Joyal JS, Mallette FA, Sapieha P. Binet F, et al. Among authors: diaz marin r. Science. 2020 Aug 21;369(6506):eaay5356. doi: 10.1126/science.aay5356. Science. 2020. PMID: 32820093