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Page 1
An atlas of protein homo-oligomerization across domains of life.
Schweke H, Pacesa M, Levin T, Goverde CA, Kumar P, Duhoo Y, Dornfeld LJ, Dubreuil B, Georgeon S, Ovchinnikov S, Woolfson DN, Correia BE, Dey S, Levy ED. Schweke H, et al. Among authors: georgeon s. Cell. 2024 Feb 15;187(4):999-1010.e15. doi: 10.1016/j.cell.2024.01.022. Epub 2024 Feb 6. Cell. 2024. PMID: 38325366 Free article.
Computational design of anti-CRISPR proteins with improved inhibition potency.
Mathony J, Harteveld Z, Schmelas C, Upmeier Zu Belzen J, Aschenbrenner S, Sun W, Hoffmann MD, Stengl C, Scheck A, Georgeon S, Rosset S, Wang Y, Grimm D, Eils R, Correia BE, Niopek D. Mathony J, et al. Among authors: georgeon s. Nat Chem Biol. 2020 Jul;16(7):725-730. doi: 10.1038/s41589-020-0518-9. Epub 2020 Apr 13. Nat Chem Biol. 2020. PMID: 32284602
De novo protein design enables the precise induction of RSV-neutralizing antibodies.
Sesterhenn F, Yang C, Bonet J, Cramer JT, Wen X, Wang Y, Chiang CI, Abriata LA, Kucharska I, Castoro G, Vollers SS, Galloux M, Dheilly E, Rosset S, Corthésy P, Georgeon S, Villard M, Richard CA, Descamps D, Delgado T, Oricchio E, Rameix-Welti MA, Más V, Ervin S, Eléouët JF, Riffault S, Bates JT, Julien JP, Li Y, Jardetzky T, Krey T, Correia BE. Sesterhenn F, et al. Among authors: georgeon s. Science. 2020 May 15;368(6492):eaay5051. doi: 10.1126/science.aay5051. Science. 2020. PMID: 32409444 Free PMC article.
Bottom-up de novo design of functional proteins with complex structural features.
Yang C, Sesterhenn F, Bonet J, van Aalen EA, Scheller L, Abriata LA, Cramer JT, Wen X, Rosset S, Georgeon S, Jardetzky T, Krey T, Fussenegger M, Merkx M, Correia BE. Yang C, et al. Among authors: georgeon s. Nat Chem Biol. 2021 Apr;17(4):492-500. doi: 10.1038/s41589-020-00699-x. Epub 2021 Jan 4. Nat Chem Biol. 2021. PMID: 33398169
A rational blueprint for the design of chemically-controlled protein switches.
Shui S, Gainza P, Scheller L, Yang C, Kurumida Y, Rosset S, Georgeon S, Di Roberto RB, Castellanos-Rueda R, Reddy ST, Correia BE. Shui S, et al. Among authors: georgeon s. Nat Commun. 2021 Oct 1;12(1):5754. doi: 10.1038/s41467-021-25735-9. Nat Commun. 2021. PMID: 34599176 Free PMC article.
De novo design of protein interactions with learned surface fingerprints.
Gainza P, Wehrle S, Van Hall-Beauvais A, Marchand A, Scheck A, Harteveld Z, Buckley S, Ni D, Tan S, Sverrisson F, Goverde C, Turelli P, Raclot C, Teslenko A, Pacesa M, Rosset S, Georgeon S, Marsden J, Petruzzella A, Liu K, Xu Z, Chai Y, Han P, Gao GF, Oricchio E, Fierz B, Trono D, Stahlberg H, Bronstein M, Correia BE. Gainza P, et al. Among authors: georgeon s. Nature. 2023 May;617(7959):176-184. doi: 10.1038/s41586-023-05993-x. Epub 2023 Apr 26. Nature. 2023. PMID: 37100904 Free PMC article.
Rational Design of Chemically Controlled Antibodies and Protein Therapeutics.
Marchand A, Bonati L, Shui S, Scheller L, Gainza P, Rosset S, Georgeon S, Tang L, Correia BE. Marchand A, et al. Among authors: georgeon s. ACS Chem Biol. 2023 Jun 16;18(6):1259-1265. doi: 10.1021/acschembio.3c00012. Epub 2023 May 30. ACS Chem Biol. 2023. PMID: 37252896 Free PMC article.
Computational design of soluble functional analogues of integral membrane proteins.
Goverde CA, Pacesa M, Goldbach N, Dornfeld LJ, Balbi PEM, Georgeon S, Rosset S, Kapoor S, Choudhury J, Dauparas J, Schellhaas C, Kozlov S, Baker D, Ovchinnikov S, Vecchio AJ, Correia BE. Goverde CA, et al. Among authors: georgeon s. bioRxiv [Preprint]. 2024 Mar 7:2023.05.09.540044. doi: 10.1101/2023.05.09.540044. bioRxiv. 2024. Update in: Nature. 2024 Jul;631(8020):449-458. doi: 10.1038/s41586-024-07601-y PMID: 38496615 Free PMC article. Updated. Preprint.
Antibody-peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins.
Petruzzella A, Bruand M, Santamaria-Martínez A, Katanayeva N, Reymond L, Wehrle S, Georgeon S, Inel D, van Dalen FJ, Viertl D, Lau K, Pojer F, Schottelius M, Zoete V, Verdoes M, Arber C, Correia BE, Oricchio E. Petruzzella A, et al. Among authors: georgeon s. Nat Chem Biol. 2024 Sep;20(9):1188-1198. doi: 10.1038/s41589-024-01627-z. Epub 2024 May 29. Nat Chem Biol. 2024. PMID: 38811854
Computational design of soluble and functional membrane protein analogues.
Goverde CA, Pacesa M, Goldbach N, Dornfeld LJ, Balbi PEM, Georgeon S, Rosset S, Kapoor S, Choudhury J, Dauparas J, Schellhaas C, Kozlov S, Baker D, Ovchinnikov S, Vecchio AJ, Correia BE. Goverde CA, et al. Among authors: georgeon s. Nature. 2024 Jul;631(8020):449-458. doi: 10.1038/s41586-024-07601-y. Epub 2024 Jun 19. Nature. 2024. PMID: 38898281 Free PMC article.
24 results