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Page 1
Targeted protein degradation via intramolecular bivalent glues.
Hsia O, Hinterndorfer M, Cowan AD, Iso K, Ishida T, Sundaramoorthy R, Nakasone MA, Imrichova H, Schätz C, Rukavina A, Husnjak K, Wegner M, Correa-Sáez A, Craigon C, Casement R, Maniaci C, Testa A, Kaulich M, Dikic I, Winter GE, Ciulli A. Hsia O, et al. Among authors: nakasone ma. Nature. 2024 Mar;627(8002):204-211. doi: 10.1038/s41586-024-07089-6. Epub 2024 Feb 21. Nature. 2024. PMID: 38383787 Free PMC article.
Mechanism of degrader-targeted protein ubiquitinability.
Crowe C, Nakasone MA, Chandler S, Craigon C, Sathe G, Tatham MH, Makukhin N, Hay RT, Ciulli A. Crowe C, et al. Among authors: nakasone ma. Sci Adv. 2024 Oct 11;10(41):eado6492. doi: 10.1126/sciadv.ado6492. Epub 2024 Oct 11. Sci Adv. 2024. PMID: 39392888 Free PMC article.
Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer.
Villar VH, Allega MF, Deshmukh R, Ackermann T, Nakasone MA, Vande Voorde J, Drake TM, Oetjen J, Bloom A, Nixon C, Müller M, May S, Tan EH, Vereecke L, Jans M, Blancke G, Murphy DJ, Huang DT, Lewis DY, Bird TG, Sansom OJ, Blyth K, Sumpton D, Tardito S. Villar VH, et al. Among authors: nakasone ma. Nat Chem Biol. 2023 Mar;19(3):292-300. doi: 10.1038/s41589-022-01154-9. Epub 2022 Oct 24. Nat Chem Biol. 2023. PMID: 36280791 Free PMC article.
Extended ubiquitin species are protein-based DUB inhibitors.
Krutauz D, Reis N, Nakasone MA, Siman P, Zhang D, Kirkpatrick DS, Gygi SP, Brik A, Fushman D, Glickman MH. Krutauz D, et al. Among authors: nakasone ma. Nat Chem Biol. 2014 Aug;10(8):664-70. doi: 10.1038/nchembio.1574. Epub 2014 Jul 6. Nat Chem Biol. 2014. PMID: 24997605 Free PMC article.
Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders.
Kroupova A, Spiteri VA, Rutter ZJ, Furihata H, Darren D, Ramachandran S, Chakraborti S, Haubrich K, Pethe J, Gonzales D, Wijaya AJ, Rodriguez-Rios M, Sturbaut M, Lynch DM, Farnaby W, Nakasone MA, Zollman D, Ciulli A. Kroupova A, et al. Among authors: nakasone ma. Nat Commun. 2024 Oct 15;15(1):8885. doi: 10.1038/s41467-024-52871-9. Nat Commun. 2024. PMID: 39406745 Free PMC article.
19 results