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Targeted protein degradation via intramolecular bivalent glues.
Hsia O, Hinterndorfer M, Cowan AD, Iso K, Ishida T, Sundaramoorthy R, Nakasone MA, Imrichova H, Schätz C, Rukavina A, Husnjak K, Wegner M, Correa-Sáez A, Craigon C, Casement R, Maniaci C, Testa A, Kaulich M, Dikic I, Winter GE, Ciulli A. Hsia O, et al. Among authors: sundaramoorthy r. Nature. 2024 Mar;627(8002):204-211. doi: 10.1038/s41586-024-07089-6. Epub 2024 Feb 21. Nature. 2024. PMID: 38383787 Free PMC article.
A non-canonical scaffold-type E3 ligase complex mediates protein UFMylation.
Peter JJ, Magnussen HM, DaRosa PA, Millrine D, Matthews SP, Lamoliatte F, Sundaramoorthy R, Kopito RR, Kulathu Y. Peter JJ, et al. Among authors: sundaramoorthy r. EMBO J. 2022 Nov 2;41(21):e111015. doi: 10.15252/embj.2022111015. Epub 2022 Sep 19. EMBO J. 2022. PMID: 36121123 Free PMC article.
The Ndc80 complex targets Bod1 to human mitotic kinetochores.
Schleicher K, Porter M, Ten Have S, Sundaramoorthy R, Porter IM, Swedlow JR. Schleicher K, et al. Among authors: sundaramoorthy r. Open Biol. 2017 Nov;7(11):170099. doi: 10.1098/rsob.170099. Open Biol. 2017. PMID: 29142109 Free PMC article.
Acute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for activation and repression of transcription.
Blümli S, Wiechens N, Wu MY, Singh V, Gierlinski M, Schweikert G, Gilbert N, Naughton C, Sundaramoorthy R, Varghese J, Gourlay R, Soares R, Clark D, Owen-Hughes T. Blümli S, et al. Among authors: sundaramoorthy r. Cell Rep. 2021 Nov 2;37(5):109943. doi: 10.1016/j.celrep.2021.109943. Cell Rep. 2021. PMID: 34731603 Free PMC article.
36 results