Chen ZS - Search Results

1

Synthesis and evaluation of WK-X-34 derivatives as P-glycoprotein (P-gp/ABCB1) inhibitors for reversing multidrug resistance.

Cao F, Li Y, Ma F, Wu Z, Li Z, Chen ZS, Cheng X, Qin JJ, Dong J. Cao F, et al. Among authors: chen zs. RSC Med Chem. 2023 Dec 7;15(2):506-518. doi: 10.1039/d3md00612c. eCollection 2024 Feb 21. RSC Med Chem. 2023. PMID: 38389882

2

Design and synthesis of human ABCB1 (P-glycoprotein) inhibitors by peptide coupling of diverse chemical scaffolds on carboxyl and amino termini of (S)-valine-derived thiazole amino acid.

Singh S, Prasad NR, Chufan EE, Patel BA, Wang YJ, Chen ZS, Ambudkar SV, Talele TT. Singh S, et al. Among authors: chen zs. J Med Chem. 2014 May 22;57(10):4058-72. doi: 10.1021/jm401966m. Epub 2014 May 7. J Med Chem. 2014. PMID: 24773054 Free PMC article.

3

Design, synthesis and biological evaluation of benzamide and phenyltetrazole derivatives with amide and urea linkers as BCRP inhibitors.

Gujarati NA, Zeng L, Gupta P, Chen ZS, Korlipara VL. Gujarati NA, et al. Among authors: chen zs. Bioorg Med Chem Lett. 2017 Oct 15;27(20):4698-4704. doi: 10.1016/j.bmcl.2017.09.009. Epub 2017 Sep 7. Bioorg Med Chem Lett. 2017. PMID: 28916341

4

Exploration of 1,2,3-triazole-pyrimidine hybrids as potent reversal agents against ABCB1-mediated multidrug resistance.

Wang B, Zhao B, Chen ZS, Pang LP, Zhao YD, Guo Q, Zhang XH, Liu Y, Liu GY, Hao-Zhang, Zhang XY, Ma LY, Liu HM. Wang B, et al. Among authors: chen zs. Eur J Med Chem. 2018 Jan 1;143:1535-1542. doi: 10.1016/j.ejmech.2017.10.041. Epub 2017 Oct 21. Eur J Med Chem. 2018. PMID: 29126726

5

Comprehensive Synthesis of Amino Acid-Derived Thiazole Peptidomimetic Analogues to Understand the Enigmatic Drug/Substrate-Binding Site of P-Glycoprotein.

Patel BA, Abel B, Barbuti AM, Velagapudi UK, Chen ZS, Ambudkar SV, Talele TT. Patel BA, et al. Among authors: chen zs. J Med Chem. 2018 Feb 8;61(3):834-864. doi: 10.1021/acs.jmedchem.7b01340. Epub 2018 Jan 23. J Med Chem. 2018. PMID: 29251928 Free PMC article.

6

Synthesis and biological evaluation of indole-based UC-112 analogs as potent and selective survivin inhibitors.

Wang Q, Arnst KE, Xue Y, Lei ZN, Ma D, Chen ZS, Miller DD, Li W. Wang Q, et al. Among authors: chen zs. Eur J Med Chem. 2018 Apr 10;149:211-224. doi: 10.1016/j.ejmech.2018.02.045. Epub 2018 Feb 19. Eur J Med Chem. 2018. PMID: 29501942 Free PMC article.

7

Discovery of 5-Cyano-6-phenylpyrimidin Derivatives Containing an Acylurea Moiety as Orally Bioavailable Reversal Agents against P-Glycoprotein-Mediated Mutidrug Resistance.

Wang B, Ma LY, Wang JQ, Lei ZN, Gupta P, Zhao YD, Li ZH, Liu Y, Zhang XH, Li YN, Zhao B, Chen ZS, Liu HM. Wang B, et al. Among authors: chen zs. J Med Chem. 2018 Jul 26;61(14):5988-6001. doi: 10.1021/acs.jmedchem.8b00335. Epub 2018 Jul 18. J Med Chem. 2018. PMID: 29975529

8

Discovery of a non-toxic [1,2,4]triazolo[1,5-a]pyrimidin-7-one (WS-10) that modulates ABCB1-mediated multidrug resistance (MDR).

Chang L, Xiao M, Yang L, Wang S, Wang SQ, Bender A, Hu A, Chen ZS, Yu B, Liu HM. Chang L, et al. Among authors: chen zs. Bioorg Med Chem. 2018 Oct 1;26(18):5006-5017. doi: 10.1016/j.bmc.2018.08.021. Epub 2018 Aug 18. Bioorg Med Chem. 2018. PMID: 30150104

9

Discovery of a non-toxic [1,2,4]triazolo[1,5-a]pyrimidin-7-one (WS-10) that modulates ABCB1-mediated multidrug resistance (MDR).

Chang L, Xiao M, Yang L, Wang S, Wang SQ, Bender A, Hu A, Chen ZS, Yu B, Liu HM. Chang L, et al. Among authors: chen zs. Bioorg Med Chem. 2018 Dec 1;26(22):5974-5985. doi: 10.1016/j.bmc.2018.10.027. Epub 2018 Nov 3. Bioorg Med Chem. 2018. PMID: 30401501

10

Medicinal chemistry strategies to discover P-glycoprotein inhibitors: An update.

Dong J, Qin Z, Zhang WD, Cheng G, Yehuda AG, Ashby CR Jr, Chen ZS, Cheng XD, Qin JJ. Dong J, et al. Among authors: chen zs. Drug Resist Updat. 2020 Mar;49:100681. doi: 10.1016/j.drup.2020.100681. Epub 2020 Jan 22. Drug Resist Updat. 2020. PMID: 32014648 Review.

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