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Page 1
Comprehensive analyses of a large human gut Bacteroidales culture collection reveal species- and strain-level diversity and evolution.
Zhang ZJ, Cole CG, Coyne MJ, Lin H, Dylla N, Smith RC, Pappas TE, Townson SA, Laliwala N, Waligurski E, Ramaswamy R, Woodson C, Burgo V, Little JC, Moran D, Rose A, McMillin M, McSpadden E, Sundararajan A, Sidebottom AM, Pamer EG, Comstock LE. Zhang ZJ, et al. Among authors: townson sa. Cell Host Microbe. 2024 Oct 9;32(10):1853-1867.e5. doi: 10.1016/j.chom.2024.08.016. Epub 2024 Sep 17. Cell Host Microbe. 2024. PMID: 39293438
Blood tumor mutational burden and response to pembrolizumab plus chemotherapy in non-small cell lung cancer: KEYNOTE-782.
Bar J, Esteban E, Rodríguez-Abreu D, Aix SP, Szalai Z, Felip E, Gottfried M, Provencio M, Robinson A, Fülöp A, Rao SB, Camidge DR, Speranza G, Townson SM, Kobie J, Ayers M, Dettman EJ, Hunkapiller N, McDaniel R, Jung B, Burkhardt D, Mauntz R, Csőszi T. Bar J, et al. Among authors: townson sm. Lung Cancer. 2024 Apr;190:107506. doi: 10.1016/j.lungcan.2024.107506. Epub 2024 Feb 17. Lung Cancer. 2024. PMID: 38422883 Free article.
Discovery of Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial Infections.
Hawryluk N, Robinson D, Shen Y, Kyne G, Bedore M, Menon S, Canan S, von Geldern T, Townson S, Gokool S, Ehrens A, Koschel M, Lhermitte-Vallarino N, Martin C, Hoerauf A, Hernandez G, Dalvie D, Specht S, Hübner MP, Scandale I. Hawryluk N, et al. Among authors: townson s. J Med Chem. 2022 Aug 25;65(16):11388-11403. doi: 10.1021/acs.jmedchem.2c00960. Epub 2022 Aug 16. J Med Chem. 2022. PMID: 35972896 Free PMC article.
Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization.
Hawryluk N, Zhiru L, Carlow C, Gokool S, Townson S, Kreiss T, Chojnowski A, Prorok M, Siekierka J, Ehrens A, Koschel M, Lhermitte-Vallarino N, Martin C, Hoerauf A, Hernandez G, Canan S, Khetani V, Zeldis J, Specht S, Hübner MP, Scandale I. Hawryluk N, et al. Among authors: townson s. Int J Parasitol Drugs Drug Resist. 2022 Aug;19:89-97. doi: 10.1016/j.ijpddr.2022.06.002. Epub 2022 Jun 23. Int J Parasitol Drugs Drug Resist. 2022. PMID: 35834918 Free PMC article.
Evaluation of the in vitro susceptibility of various filarial nematodes to emodepside.
Hübner MP, Townson S, Gokool S, Tagboto S, Maclean MJ, Verocai GG, Wolstenholme AJ, Frohberger SJ, Hoerauf A, Specht S, Scandale I, Harder A, Glenschek-Sieberth M, Hahnel SR, Kulke D. Hübner MP, et al. Among authors: townson s. Int J Parasitol Drugs Drug Resist. 2021 Dec;17:27-35. doi: 10.1016/j.ijpddr.2021.07.005. Epub 2021 Jul 28. Int J Parasitol Drugs Drug Resist. 2021. PMID: 34339934 Free PMC article.
Development of emodepside as a possible adulticidal treatment for human onchocerciasis-The fruit of a successful industrial-academic collaboration.
Krücken J, Holden-Dye L, Keiser J, Prichard RK, Townson S, Makepeace BL, Hübner MP, Hahnel SR, Scandale I, Harder A, Kulke D. Krücken J, et al. Among authors: townson s. PLoS Pathog. 2021 Jul 22;17(7):e1009682. doi: 10.1371/journal.ppat.1009682. eCollection 2021 Jul. PLoS Pathog. 2021. PMID: 34293063 Free PMC article. Review.
Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro.
Hübner MP, Martin C, Specht S, Koschel M, Dubben B, Frohberger SJ, Ehrens A, Fendler M, Struever D, Mitre E, Vallarino-Lhermitte N, Gokool S, Lustigman S, Schneider M, Townson S, Hoerauf A, Scandale I. Hübner MP, et al. Among authors: townson s. PLoS Negl Trop Dis. 2020 Jul 6;14(7):e0008427. doi: 10.1371/journal.pntd.0008427. eCollection 2020 Jul. PLoS Negl Trop Dis. 2020. PMID: 32628671 Free PMC article.
Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface.
Shigdel UK, Lee SJ, Sowa ME, Bowman BR, Robison K, Zhou M, Pua KH, Stiles DT, Blodgett JAV, Udwary DW, Rajczewski AT, Mann AS, Mostafavi S, Hardy T, Arya S, Weng Z, Stewart M, Kenyon K, Morgenstern JP, Pan E, Gray DC, Pollock RM, Fry AM, Klausner RD, Townson SA, Verdine GL. Shigdel UK, et al. Among authors: townson sa. Proc Natl Acad Sci U S A. 2020 Jul 21;117(29):17195-17203. doi: 10.1073/pnas.2006560117. Epub 2020 Jun 30. Proc Natl Acad Sci U S A. 2020. PMID: 32606248 Free PMC article.
83 results