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126 results

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Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments.
Sun K, Jiang P, Chan KC, Wong J, Cheng YK, Liang RH, Chan WK, Ma ES, Chan SL, Cheng SH, Chan RW, Tong YK, Ng SS, Wong RS, Hui DS, Leung TN, Leung TY, Lai PB, Chiu RW, Lo YM. Sun K, et al. Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):E5503-12. doi: 10.1073/pnas.1508736112. Epub 2015 Sep 21. Proc Natl Acad Sci U S A. 2015. PMID: 26392541 Free PMC article.
DNA of Erythroid Origin Is Present in Human Plasma and Informs the Types of Anemia.
Lam WKJ, Gai W, Sun K, Wong RSM, Chan RWY, Jiang P, Chan NPH, Hui WWI, Chan AWH, Szeto CC, Ng SC, Law MF, Chan KCA, Chiu RWK, Lo YMD. Lam WKJ, et al. Among authors: chan awh, chan rwy, chan nph, chan kca. Clin Chem. 2017 Oct;63(10):1614-1623. doi: 10.1373/clinchem.2017.272401. Epub 2017 Aug 7. Clin Chem. 2017. PMID: 28784691
Dnase1l3 deletion causes aberrations in length and end-motif frequencies in plasma DNA.
Serpas L, Chan RWY, Jiang P, Ni M, Sun K, Rashidfarrokhi A, Soni C, Sisirak V, Lee WS, Cheng SH, Peng W, Chan KCA, Chiu RWK, Reizis B, Lo YMD. Serpas L, et al. Among authors: chan rwy, chan kca. Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):641-649. doi: 10.1073/pnas.1815031116. Epub 2018 Dec 28. Proc Natl Acad Sci U S A. 2019. PMID: 30593563 Free PMC article.
Plasma DNA End-Motif Profiling as a Fragmentomic Marker in Cancer, Pregnancy, and Transplantation.
Jiang P, Sun K, Peng W, Cheng SH, Ni M, Yeung PC, Heung MMS, Xie T, Shang H, Zhou Z, Chan RWY, Wong J, Wong VWS, Poon LC, Leung TY, Lam WKJ, Chan JYK, Chan HLY, Chan KCA, Chiu RWK, Lo YMD. Jiang P, et al. Among authors: chan rwy, chan hly, chan kca, chan jyk. Cancer Discov. 2020 May;10(5):664-673. doi: 10.1158/2159-8290.CD-19-0622. Epub 2020 Feb 28. Cancer Discov. 2020. PMID: 32111602
Detection and characterization of jagged ends of double-stranded DNA in plasma.
Jiang P, Xie T, Ding SC, Zhou Z, Cheng SH, Chan RWY, Lee WS, Peng W, Wong J, Wong VWS, Chan HLY, Chan SL, Poon LCY, Leung TY, Chan KCA, Chiu RWK, Lo YMD. Jiang P, et al. Among authors: chan rwy, chan hly, chan kca, chan sl. Genome Res. 2020 Aug;30(8):1144-1153. doi: 10.1101/gr.261396.120. Epub 2020 Aug 14. Genome Res. 2020. PMID: 32801148 Free PMC article.
Plasma DNA Profile Associated with DNASE1L3 Gene Mutations: Clinical Observations, Relationships to Nuclease Substrate Preference, and In Vivo Correction.
Chan RWY, Serpas L, Ni M, Volpi S, Hiraki LT, Tam LS, Rashidfarrokhi A, Wong PCH, Tam LHP, Wang Y, Jiang P, Cheng ASH, Peng W, Han DSC, Tse PPP, Lau PK, Lee WS, Magnasco A, Buti E, Sisirak V, AlMutairi N, Chan KCA, Chiu RWK, Reizis B, Lo YMD. Chan RWY, et al. Among authors: chan kca. Am J Hum Genet. 2020 Nov 5;107(5):882-894. doi: 10.1016/j.ajhg.2020.09.006. Epub 2020 Oct 5. Am J Hum Genet. 2020. PMID: 33022220 Free PMC article.
Nuclease deficiencies alter plasma cell-free DNA methylation profiles.
Han DSC, Ni M, Chan RWY, Wong DKL, Hiraki LT, Volpi S, Jiang P, Lui KO, Chan KCA, Chiu RWK, Lo YMD. Han DSC, et al. Among authors: chan rwy, chan kca. Genome Res. 2021 Nov;31(11):2008-2021. doi: 10.1101/gr.275426.121. Epub 2021 Sep 1. Genome Res. 2021. PMID: 34470801 Free PMC article.
126 results