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A novel MYB::PAIP1 oncogenic fusion in pediatric blastic plasmacytoid dendritic cell neoplasm (BPDCN) is dependent on BCL2 expression and is sensitive to venetoclax.
Kosasih HJ, Healey G, Brennan MS, Bjelosevic S, Sadras T, Jalud FB, Ibnat T, Ng AP, Mayoh C, Mao J, Tax G, Ludlow LEA, Johnstone RW, Herold MJ, Khaw SL, de Bock CE, Ekert PG. Kosasih HJ, et al. Among authors: de bock ce. Hemasphere. 2024 Feb 14;8(2):e1. doi: 10.1002/hem3.1. eCollection 2024 Feb. Hemasphere. 2024. PMID: 38435422 Free PMC article. No abstract available.
The tumor suppressor Fat1 is dispensable for normal murine hematopoiesis.
Zhang Q, Li MK, Hu XY, Wu YX, Wang YY, Zhao PP, Cheng LN, Yu RH, Zhang XD, Chen S, Zhu ZM, de Bock CE, Thorne RF. Zhang Q, et al. Among authors: de bock ce. J Leukoc Biol. 2024 Oct 1;116(4):909-914. doi: 10.1093/jleuko/qiae128. J Leukoc Biol. 2024. PMID: 38833591
PU.1 eviction at lymphocyte-specific chromatin domains mediates glucocorticoid response in acute lymphoblastic leukemia.
Beck D, Cao H, Tian F, Huang Y, Jiang M, Zhao H, Tai X, Xu W, Kosasih HJ, Kealy DJ, Zhao W, Taylor SJ, Couttas TA, Song G, Chacon-Fajardo D, Walia Y, Wang M, Dowle AA, Holding AN, Bridge KS, Zhang C, Wang J, Mi JQ, Lock RB, de Bock CE, Jing D. Beck D, et al. Among authors: de bock ce. Nat Commun. 2024 Nov 8;15(1):9697. doi: 10.1038/s41467-024-54096-2. Nat Commun. 2024. PMID: 39516193 Free PMC article.
The third generation AKR1C3-activated prodrug, ACHM-025, eradicates disease in preclinical models of aggressive T-cell acute lymphoblastic leukemia.
Toscan CE, McCalmont H, Ashoorzadeh A, Lin X, Fu Z, Doculara L, Kosasih HJ, Cadiz R, Zhou A, Williams S, Evans K, Khalili F, Cai R, Yeats KL, Gifford AJ, Pickford R, Mayoh C, Xie J, Henderson MJ, Trahair TN, Patterson AV, Smaill JB, de Bock CE, Lock RB. Toscan CE, et al. Among authors: de bock ce. Blood Cancer J. 2024 Nov 6;14(1):192. doi: 10.1038/s41408-024-01180-x. Blood Cancer J. 2024. PMID: 39505850 Free PMC article.
Selective targeting of malignant T cells.
de Bock CE, Cools J. de Bock CE, et al. Nat Cancer. 2024 Jun;5(6):823-824. doi: 10.1038/s43018-024-00778-1. Nat Cancer. 2024. PMID: 38816659 No abstract available.
74 results