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Metagenomic study of lake microbial mats reveals protease-inhibiting antiviral peptides from a core microbiome member.
Padhi C, Field CM, Forneris CC, Olszewski D, Fraley AE, Sandu I, Scott TA, Farnung J, Ruscheweyh HJ, Narayan Panda A, Oxenius A, Greber UF, Bode JW, Sunagawa S, Raina V, Suar M, Piel J. Padhi C, et al. Among authors: piel j. Proc Natl Acad Sci U S A. 2024 Dec 3;121(49):e2409026121. doi: 10.1073/pnas.2409026121. Epub 2024 Nov 25. Proc Natl Acad Sci U S A. 2024. PMID: 39585984
Ribosomal peptides with polycyclic isoprenoid moieties.
Hubrich F, Kandy SK, Chepkirui C, Padhi C, Mordhorst S, Moosmann P, Zhu T, Gugger M, Chekan JR, Piel J. Hubrich F, et al. Among authors: piel j. Chem. 2024 Oct 10;10(10):3224-3242. doi: 10.1016/j.chempr.2024.07.026. Epub 2024 Sep 6. Chem. 2024. PMID: 39429465
Novel types of RiPP-modifying enzymes.
Richter D, Piel J. Richter D, et al. Among authors: piel j. Curr Opin Chem Biol. 2024 Jun;80:102463. doi: 10.1016/j.cbpa.2024.102463. Epub 2024 May 9. Curr Opin Chem Biol. 2024. PMID: 38729090 Free article. Review.
Evolution-guided engineering of trans-acyltransferase polyketide synthases.
Mabesoone MFJ, Leopold-Messer S, Minas HA, Chepkirui C, Chawengrum P, Reiter S, Meoded RA, Wolf S, Genz F, Magnus N, Piechulla B, Walker AS, Piel J. Mabesoone MFJ, et al. Among authors: piel j. Science. 2024 Mar 22;383(6689):1312-1317. doi: 10.1126/science.adj7621. Epub 2024 Mar 21. Science. 2024. PMID: 38513027 Free PMC article.
BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or menin inhibitor.
Fiskus W, Piel J, Collins M, Hentemann M, Cuglievan B, Mill CP, Birdwell CE, Das K, Davis JA, Hou H, Jain A, Malovannaya A, Kadia TM, Daver N, Sasaki K, Takahashi K, Hammond D, Reville PK, Wang J, Loghavi S, Sen R, Ruan X, Su X, Flores LB, DiNardo CD, Bhalla KN. Fiskus W, et al. Among authors: piel j. Blood. 2024 May 16;143(20):2059-2072. doi: 10.1182/blood.2023022832. Blood. 2024. PMID: 38437498
240 results