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TIM-3, LAG-3, or 2B4 gene disruptions increase the anti-tumor response of engineered T cells.
Cianciotti BC, Magnani ZI, Ugolini A, Camisa B, Merelli I, Vavassori V, Potenza A, Imparato A, Manfredi F, Abbati D, Perani L, Spinelli A, Shifrut E, Ciceri F, Vago L, Di Micco R, Naldini L, Genovese P, Ruggiero E, Bonini C. Cianciotti BC, et al. Among authors: manfredi f. Front Immunol. 2024 Feb 29;15:1315283. doi: 10.3389/fimmu.2024.1315283. eCollection 2024. Front Immunol. 2024. PMID: 38510235 Free PMC article.
Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT.
Noviello M, Manfredi F, Ruggiero E, Perini T, Oliveira G, Cortesi F, De Simone P, Toffalori C, Gambacorta V, Greco R, Peccatori J, Casucci M, Casorati G, Dellabona P, Onozawa M, Teshima T, Griffioen M, Halkes CJM, Falkenburg JHF, Stölzel F, Altmann H, Bornhäuser M, Waterhouse M, Zeiser R, Finke J, Cieri N, Bondanza A, Vago L, Ciceri F, Bonini C. Noviello M, et al. Among authors: manfredi f. Nat Commun. 2019 Mar 25;10(1):1065. doi: 10.1038/s41467-019-08871-1. Nat Commun. 2019. PMID: 30911002 Free PMC article.
Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation.
Toffalori C, Zito L, Gambacorta V, Riba M, Oliveira G, Bucci G, Barcella M, Spinelli O, Greco R, Crucitti L, Cieri N, Noviello M, Manfredi F, Montaldo E, Ostuni R, Naldini MM, Gentner B, Waterhouse M, Zeiser R, Finke J, Hanoun M, Beelen DW, Gojo I, Luznik L, Onozawa M, Teshima T, Devillier R, Blaise D, Halkes CJM, Griffioen M, Carrabba MG, Bernardi M, Peccatori J, Barlassina C, Stupka E, Lazarevic D, Tonon G, Rambaldi A, Cittaro D, Bonini C, Fleischhauer K, Ciceri F, Vago L. Toffalori C, et al. Among authors: manfredi f. Nat Med. 2019 Apr;25(4):603-611. doi: 10.1038/s41591-019-0400-z. Epub 2019 Mar 25. Nat Med. 2019. PMID: 30911134
Flow cytometry data mining by cytoChain identifies determinants of exhaustion and stemness in TCR-engineered T cells.
Manfredi F, Abbati D, Cianciotti BC, Stasi L, Potenza A, Ruggiero E, Magnani Z, Carnevale E, Doglio M, Noviello M, Tassi E, Balestrieri C, Buonanno S, Clemente F, De Lalla C, Protti MP, Mondino A, Casorati G, Dellabona P, Bonini C. Manfredi F, et al. Eur J Immunol. 2021 Aug;51(8):1992-2005. doi: 10.1002/eji.202049103. Epub 2021 Jun 21. Eur J Immunol. 2021. PMID: 34081326 Free article.
Disrupting N-glycan expression on tumor cells boosts chimeric antigen receptor T cell efficacy against solid malignancies.
Greco B, Malacarne V, De Girardi F, Scotti GM, Manfredi F, Angelino E, Sirini C, Camisa B, Falcone L, Moresco MA, Paolella K, Di Bono M, Norata R, Sanvito F, Arcangeli S, Doglioni C, Ciceri F, Bonini C, Graziani A, Bondanza A, Casucci M. Greco B, et al. Among authors: manfredi f. Sci Transl Med. 2022 Jan 19;14(628):eabg3072. doi: 10.1126/scitranslmed.abg3072. Epub 2022 Jan 19. Sci Transl Med. 2022. PMID: 35044789
CRISPR-based gene disruption and integration of high-avidity, WT1-specific T cell receptors improve antitumor T cell function.
Ruggiero E, Carnevale E, Prodeus A, Magnani ZI, Camisa B, Merelli I, Politano C, Stasi L, Potenza A, Cianciotti BC, Manfredi F, Di Bono M, Vago L, Tassara M, Mastaglio S, Ponzoni M, Sanvito F, Liu D, Balwani I, Galli R, Genua M, Ostuni R, Doglio M, O'Connell D, Dutta I, Yazinski SA, McKee M, Arredouani MS, Schultes B, Ciceri F, Bonini C. Ruggiero E, et al. Among authors: manfredi f. Sci Transl Med. 2022 Feb 9;14(631):eabg8027. doi: 10.1126/scitranslmed.abg8027. Epub 2022 Feb 9. Sci Transl Med. 2022. PMID: 35138911
CAR T cell manufacturing from naive/stem memory T lymphocytes enhances antitumor responses while curtailing cytokine release syndrome.
Arcangeli S, Bove C, Mezzanotte C, Camisa B, Falcone L, Manfredi F, Bezzecchi E, El Khoury R, Norata R, Sanvito F, Ponzoni M, Greco B, Moresco MA, Carrabba MG, Ciceri F, Bonini C, Bondanza A, Casucci M. Arcangeli S, et al. Among authors: manfredi f. J Clin Invest. 2022 Jun 15;132(12):e150807. doi: 10.1172/JCI150807. J Clin Invest. 2022. PMID: 35503659 Free PMC article.
Workflow for high-dimensional flow cytometry analysis of T cells from tumor metastases.
Faccani C, Rotta G, Clemente F, Fedeli M, Abbati D, Manfredi F, Potenza A, Anselmo A, Pedica F, Fiorentini G, Villa C, Protti MP, Doglioni C, Aldrighetti L, Bonini C, Casorati G, Dellabona P, de Lalla C. Faccani C, et al. Among authors: manfredi f. Life Sci Alliance. 2022 Jun 3;5(10):e202101316. doi: 10.26508/lsa.202101316. Print 2022 Oct. Life Sci Alliance. 2022. PMID: 35724271 Free PMC article.
Cytomegalovirus-specific T cells restricted for shared and donor human leukocyte antigens differentially impact on cytomegalovirus reactivation risk after allogeneic hematopoietic stem cell transplantation.
Tassi E, Noviello M, De Simone P, Lupo-Stanghellini MT, Doglio M, Serio F, Abbati D, Beretta V, Valtolina V, Oliveira G, Racca S, Campodonico E, Ruggiero E, Clerici D, Giglio F, Lorentino F, Dvir R, Xue E, Farina F, Oltolini C, Manfredi F, Vago L, Corti C, Bernardi M, Clementi M, Brix L, Ciceri F, Peccatori J, Greco R, Bonini C. Tassi E, et al. Among authors: manfredi f. Haematologica. 2023 Jun 1;108(6):1530-1543. doi: 10.3324/haematol.2022.280685. Haematologica. 2023. PMID: 36200418 Free PMC article.
165 results