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The J bs-5YP peptide can alleviate dementia in senile mice by restoring the transcription of Slc40a1 to secrete the excessive iron from brain.
Zou Z, Wu F, Chen L, Yao H, Wang Z, Chen Y, Qi M, Jiang Y, Tang L, Gan X, Kong L, Yang Z, Huang X, Shu W, Li B, Tan X, Huang L, Bai S, Wu L, Mo J, Hu H, Liu H, Zou R, Wei Y. Zou Z, et al. Among authors: wu f, wu l. J Adv Res. 2024 Mar 23:S2090-1232(24)00114-0. doi: 10.1016/j.jare.2024.03.014. Online ahead of print. J Adv Res. 2024. PMID: 38527587 Free article.
Using the synthesized peptide HAYED (5) to protect the brain against iron catalyzed radical attack in a naturally senescence Kunming mouse model.
Zou Z, Cai J, Zhong A, Zhou Y, Wang Z, Wu Z, Yang Y, Li X, Cheng X, Tan J, Fan Y, Zhang X, Lu Y, Zhou Y, Yang L, Zhang C, Zhao Q, Fu D, Shen Q, Chen J, Bai S, Wu L, Chen Y, Chen X, Chen J, Zheng H, Wang H, Lou Y, Ding Y, Shen S, Ye Y, Chen L, Lin Y, Huang J, Zou K, Zhang J, Bian B, Huang C, Rong C, Dai L, Xu Y, Cheng L, Chen Y, Luo Y, Zhang S, Li L. Zou Z, et al. Among authors: wu l, wu z. Free Radic Biol Med. 2019 Jan;130:458-470. doi: 10.1016/j.freeradbiomed.2018.11.014. Epub 2018 Nov 15. Free Radic Biol Med. 2019. PMID: 30448512
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