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Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4.
Yuan M, Peng L, Huang D, Gavin A, Luan F, Tran J, Feng Z, Zhu X, Matteson J, Wilson IA, Nemazee D. Yuan M, et al. Among authors: huang d. bioRxiv [Preprint]. 2023 Nov 20:2023.11.20.567917. doi: 10.1101/2023.11.20.567917. bioRxiv. 2023. Update in: Structure. 2024 Jun 6;32(6):766-779.e7. doi: 10.1016/j.str.2024.02.019. PMID: 38045427 Free PMC article. Updated. Preprint.
PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing.
Gavin AL, Huang D, Huber C, Mårtensson A, Tardif V, Skog PD, Blane TR, Thinnes TC, Osborn K, Chong HS, Kargaran F, Kimm P, Zeitjian A, Sielski RL, Briggs M, Schulz SR, Zarpellon A, Cravatt B, Pang ES, Teijaro J, de la Torre JC, O'Keeffe M, Hochrein H, Damme M, Teyton L, Lawson BR, Nemazee D. Gavin AL, et al. Among authors: huang d. Nat Immunol. 2018 Sep;19(9):942-953. doi: 10.1038/s41590-018-0179-y. Epub 2018 Aug 13. Nat Immunol. 2018. PMID: 30111894 Free PMC article.
Structural basis of a shared antibody response to SARS-CoV-2.
Yuan M, Liu H, Wu NC, Lee CD, Zhu X, Zhao F, Huang D, Yu W, Hua Y, Tien H, Rogers TF, Landais E, Sok D, Jardine JG, Burton DR, Wilson IA. Yuan M, et al. Among authors: huang d. Science. 2020 Aug 28;369(6507):1119-1123. doi: 10.1126/science.abd2321. Epub 2020 Jul 13. Science. 2020. PMID: 32661058 Free PMC article.
A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibody.
Wu NC, Yuan M, Bangaru S, Huang D, Zhu X, Lee CD, Turner HL, Peng L, Yang L, Nemazee D, Ward AB, Wilson IA. Wu NC, et al. Among authors: huang d. bioRxiv [Preprint]. 2020 Sep 21:2020.09.21.305441. doi: 10.1101/2020.09.21.305441. bioRxiv. 2020. Update in: PLoS Pathog. 2020 Dec 4;16(12):e1009089. doi: 10.1371/journal.ppat.1009089. PMID: 32995788 Free PMC article. Updated. Preprint.
A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection.
Liu H, Yuan M, Huang D, Bangaru S, Lee CD, Peng L, Zhu X, Nemazee D, van Gils MJ, Sanders RW, Kornau HC, Reincke SM, Prüss H, Kreye J, Wu NC, Ward AB, Wilson IA. Liu H, et al. Among authors: huang d. bioRxiv [Preprint]. 2021 Feb 12:2021.02.11.430866. doi: 10.1101/2021.02.11.430866. bioRxiv. 2021. Update in: Cell Host Microbe. 2021 May 12;29(5):806-818.e6. doi: 10.1016/j.chom.2021.04.005. PMID: 33594361 Free PMC article. Updated. Preprint.
Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants.
Yuan M, Huang D, Lee CD, Wu NC, Jackson AM, Zhu X, Liu H, Peng L, van Gils MJ, Sanders RW, Burton DR, Reincke SM, Prüss H, Kreye J, Nemazee D, Ward AB, Wilson IA. Yuan M, et al. Among authors: huang d. bioRxiv [Preprint]. 2021 Feb 17:2021.02.16.430500. doi: 10.1101/2021.02.16.430500. bioRxiv. 2021. Update in: Science. 2021 Aug 13;373(6556):818-823. doi: 10.1126/science.abh1139. PMID: 33619487 Free PMC article. Updated. Preprint.
A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection.
Liu H, Yuan M, Huang D, Bangaru S, Zhao F, Lee CD, Peng L, Barman S, Zhu X, Nemazee D, Burton DR, van Gils MJ, Sanders RW, Kornau HC, Reincke SM, Prüss H, Kreye J, Wu NC, Ward AB, Wilson IA. Liu H, et al. Among authors: huang d. Cell Host Microbe. 2021 May 12;29(5):806-818.e6. doi: 10.1016/j.chom.2021.04.005. Epub 2021 Apr 15. Cell Host Microbe. 2021. PMID: 33894127 Free PMC article.
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