Pasinelli P - Search Results

1

The nuclear import receptor Kapβ2 modifies neurotoxicity mediated by poly(GR) in C9orf72-linked ALS/FTD.

Cicardi ME, Kankate V, Sriramoji S, Krishnamurthy K, Markandaiah SS, Verdone BM, Girdhar A, Nelson A, Rivas LB, Boehringer A, Haeusler AR, Pasinelli P, Guo L, Trotti D. Cicardi ME, et al. Among authors: pasinelli p. Commun Biol. 2024 Mar 28;7(1):376. doi: 10.1038/s42003-024-06071-2. Commun Biol. 2024. PMID: 38548902 Free PMC article.

2

A caspase-3-cleaved fragment of the glial glutamate transporter EAAT2 is sumoylated and targeted to promyelocytic leukemia nuclear bodies in mutant SOD1-linked amyotrophic lateral sclerosis.

Gibb SL, Boston-Howes W, Lavina ZS, Gustincich S, Brown RH Jr, Pasinelli P, Trotti D. Gibb SL, et al. Among authors: pasinelli p. J Biol Chem. 2007 Nov 2;282(44):32480-90. doi: 10.1074/jbc.M704314200. Epub 2007 Sep 6. J Biol Chem. 2007. PMID: 17823119 Free article.

3

Nordihydroguaiaretic acid increases glutamate uptake in vitro and in vivo: therapeutic implications for amyotrophic lateral sclerosis.

Boston-Howes W, Williams EO, Bogush A, Scolere M, Pasinelli P, Trotti D. Boston-Howes W, et al. Among authors: pasinelli p. Exp Neurol. 2008 Sep;213(1):229-37. doi: 10.1016/j.expneurol.2008.06.010. Epub 2008 Jun 24. Exp Neurol. 2008. PMID: 18625223 Free PMC article.

4

ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2.

Pedrini S, Sau D, Guareschi S, Bogush M, Brown RH Jr, Naniche N, Kia A, Trotti D, Pasinelli P. Pedrini S, et al. Among authors: pasinelli p. Hum Mol Genet. 2010 Aug 1;19(15):2974-86. doi: 10.1093/hmg/ddq202. Epub 2010 May 11. Hum Mol Genet. 2010. PMID: 20460269 Free PMC article.

5

Voltage-dependent inwardly rectifying potassium conductance in the outer membrane of neuronal mitochondria.

Fieni F, Parkar A, Misgeld T, Kerschensteiner M, Lichtman JW, Pasinelli P, Trotti D. Fieni F, et al. Among authors: pasinelli p. J Biol Chem. 2010 Aug 27;285(35):27411-27417. doi: 10.1074/jbc.M110.131243. Epub 2010 Jun 15. J Biol Chem. 2010. PMID: 20551319 Free PMC article.

6

Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2.

Foran E, Bogush A, Goffredo M, Roncaglia P, Gustincich S, Pasinelli P, Trotti D. Foran E, et al. Among authors: pasinelli p. Glia. 2011 Nov;59(11):1719-31. doi: 10.1002/glia.21218. Epub 2011 Jul 18. Glia. 2011. PMID: 21769946 Free PMC article.

7

An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1.

Guareschi S, Cova E, Cereda C, Ceroni M, Donetti E, Bosco DA, Trotti D, Pasinelli P. Guareschi S, et al. Among authors: pasinelli p. Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5074-9. doi: 10.1073/pnas.1115402109. Epub 2012 Mar 13. Proc Natl Acad Sci U S A. 2012. PMID: 22416121 Free PMC article.

8

Selective increase of two ABC drug efflux transporters at the blood-spinal cord barrier suggests induced pharmacoresistance in ALS.

Jablonski MR, Jacob DA, Campos C, Miller DS, Maragakis NJ, Pasinelli P, Trotti D. Jablonski MR, et al. Among authors: pasinelli p. Neurobiol Dis. 2012 Aug;47(2):194-200. doi: 10.1016/j.nbd.2012.03.040. Epub 2012 Apr 11. Neurobiol Dis. 2012. PMID: 22521463 Free PMC article.

9

Small peptides against the mutant SOD1/Bcl-2 toxic mitochondrial complex restore mitochondrial function and cell viability in mutant SOD1-mediated ALS.

Tan W, Naniche N, Bogush A, Pedrini S, Trotti D, Pasinelli P. Tan W, et al. Among authors: pasinelli p. J Neurosci. 2013 Jul 10;33(28):11588-98. doi: 10.1523/JNEUROSCI.5385-12.2013. J Neurosci. 2013. PMID: 23843527 Free PMC article.

10

Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis.

Tan W, Pasinelli P, Trotti D. Tan W, et al. Among authors: pasinelli p. Biochim Biophys Acta. 2014 Aug;1842(8):1295-301. doi: 10.1016/j.bbadis.2014.02.009. Epub 2014 Feb 22. Biochim Biophys Acta. 2014. PMID: 24568860 Free PMC article. Review.

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