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Page 1
RTP801 interacts with the tRNA ligase complex and dysregulates its RNA ligase activity in Alzheimer's disease.
Campoy-Campos G, Solana-Balaguer J, Guisado-Corcoll A, Chicote-González A, Garcia-Segura P, Pérez-Sisqués L, Torres AG, Canal M, Molina-Porcel L, Fernández-Irigoyen J, Santamaria E, Ribas de Pouplana L, Alberch J, Martí E, Giralt A, Pérez-Navarro E, Malagelada C. Campoy-Campos G, et al. Among authors: perez sisques l. Nucleic Acids Res. 2024 Oct 14;52(18):11158-11176. doi: 10.1093/nar/gkae776. Nucleic Acids Res. 2024. PMID: 39268577 Free PMC article.
RTP801 mediates transneuronal toxicity in culture via extracellular vesicles.
Solana-Balaguer J, Martín-Flores N, Garcia-Segura P, Campoy-Campos G, Pérez-Sisqués L, Chicote-González A, Fernández-Irigoyen J, Santamaría E, Pérez-Navarro E, Alberch J, Malagelada C. Solana-Balaguer J, et al. Among authors: perez sisques l. J Extracell Vesicles. 2023 Nov;12(11):e12378. doi: 10.1002/jev2.12378. J Extracell Vesicles. 2023. PMID: 37932242 Free PMC article.
Neuron-derived extracellular vesicles contain synaptic proteins, promote spine formation, activate TrkB-mediated signalling and preserve neuronal complexity.
Solana-Balaguer J, Campoy-Campos G, Martín-Flores N, Pérez-Sisqués L, Sitjà-Roqueta L, Kucukerden M, Gámez-Valero A, Coll-Manzano A, Martí E, Pérez-Navarro E, Alberch J, Soriano J, Masana M, Malagelada C. Solana-Balaguer J, et al. Among authors: perez sisques l. J Extracell Vesicles. 2023 Sep;12(9):e12355. doi: 10.1002/jev2.12355. J Extracell Vesicles. 2023. PMID: 37743539 Free PMC article.
Tcf20 deficiency is associated with increased liver fibrogenesis and alterations in mitochondrial metabolism in mice and humans.
Córdoba-Jover B, Ribera J, Portolés I, Lecue E, Rodriguez-Vita J, Pérez-Sisqués L, Mannara F, Solsona-Vilarrasa E, García-Ruiz C, Fernández-Checa JC, Casals G, Rodríguez-Revenga L, Álvarez-Mora MI, Arteche-López A, Díaz de Bustamante A, Calvo R, Pujol A, Azkargorta M, Elortza F, Malagelada C, Pinyol R, Huguet-Pradell J, Melgar-Lesmes P, Jiménez W, Morales-Ruiz M. Córdoba-Jover B, et al. Among authors: perez sisques l. Liver Int. 2023 Aug;43(8):1822-1836. doi: 10.1111/liv.15640. Epub 2023 Jun 14. Liver Int. 2023. PMID: 37312667
Increased Phospho-AKT in Blood Cells from LRRK2 G2019S Mutation Carriers.
Garrido A, Pérez-Sisqués L, Simonet C, Campoy-Campos G, Solana-Balaguer J, Martín-Flores N, Fernández M, Soto M, Obiang D, Cámara A, Valldeoriola F, Muñoz E, Compta Y, Pérez-Navarro E, Alberch J, Tolosa E, Martí MJ, Ezquerra M, Malagelada C, Fernández-Santiago R. Garrido A, et al. Among authors: perez sisques l. Ann Neurol. 2022 Nov;92(5):888-894. doi: 10.1002/ana.26469. Epub 2022 Sep 26. Ann Neurol. 2022. PMID: 35929078 Free PMC article.
R1441G but not G2019S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophils.
Fan Y, Nirujogi RS, Garrido A, Ruiz-Martínez J, Bergareche-Yarza A, Mondragón-Rezola E, Vinagre-Aragón A, Croitoru I, Gorostidi Pagola A, Paternain Markinez L, Alcalay R, Hickman RA, Düring J, Gomes S, Pratuseviciute N, Padmanabhan S, Valldeoriola F, Pérez Sisqués L, Malagelada C, Ximelis T, Molina Porcel L, Martí MJ, Tolosa E, Alessi DR, Sammler EM. Fan Y, et al. Among authors: perez sisques l. Acta Neuropathol. 2021 Sep;142(3):475-494. doi: 10.1007/s00401-021-02325-z. Epub 2021 Jun 14. Acta Neuropathol. 2021. PMID: 34125248 Free PMC article.
RTP801 regulates motor cortex synaptic transmission and learning.
Pérez-Sisqués L, Martín-Flores N, Masana M, Solana-Balaguer J, Llobet A, Romaní-Aumedes J, Canal M, Campoy-Campos G, García-García E, Sánchez-Fernández N, Fernández-García S, Gilbert JP, Rodríguez MJ, Man HY, Feinstein E, Williamson DL, Soto D, Gasull X, Alberch J, Malagelada C. Pérez-Sisqués L, et al. Exp Neurol. 2021 Aug;342:113755. doi: 10.1016/j.expneurol.2021.113755. Epub 2021 May 11. Exp Neurol. 2021. PMID: 33984337 Free article.
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