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Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy.
Parmasad JA, Ricke KM, Nguyen B, Stykel MG, Buchner-Duby B, Bruce A, Geertsma HM, Lian E, Lengacher NA, Callaghan SM, Joselin A, Tomlinson JJ, Schlossmacher MG, Stanford WL, Ma J, Brundin P, Ryan SD, Rousseaux MWC. Parmasad JA, et al. Among authors: callaghan sm. Cell Death Dis. 2024 Apr 4;15(4):246. doi: 10.1038/s41419-024-06534-8. Cell Death Dis. 2024. PMID: 38575601 Free PMC article.
DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway.
Aleyasin H, Rousseaux MW, Marcogliese PC, Hewitt SJ, Irrcher I, Joselin AP, Parsanejad M, Kim RH, Rizzu P, Callaghan SM, Slack RS, Mak TW, Park DS. Aleyasin H, et al. Among authors: callaghan sm. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3186-91. doi: 10.1073/pnas.0914876107. Epub 2010 Jan 26. Proc Natl Acad Sci U S A. 2010. PMID: 20133695 Free PMC article.
Age-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites.
Tokarew JM, El-Kodsi DN, Lengacher NA, Fehr TK, Nguyen AP, Shutinoski B, O'Nuallain B, Jin M, Khan JM, Ng ACH, Li J, Jiang Q, Zhang M, Wang L, Sengupta R, Barber KR, Tran A, Im DS, Callaghan S, Park DS, Zandee S, Dong X, Scherzer CR, Prat A, Tsai EC, Takanashi M, Hattori N, Chan JA, Zecca L, West AB, Holmgren A, Puente L, Shaw GS, Toth G, Woulfe JM, Taylor P, Tomlinson JJ, Schlossmacher MG. Tokarew JM, et al. Acta Neuropathol. 2021 May;141(5):725-754. doi: 10.1007/s00401-021-02285-4. Epub 2021 Mar 10. Acta Neuropathol. 2021. PMID: 33694021 Free PMC article.
Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson's disease.
Kim KS, Marcogliese PC, Yang J, Callaghan SM, Resende V, Abdel-Messih E, Marras C, Visanji NP, Huang J, Schlossmacher MG, Trinkle-Mulcahy L, Slack RS, Lang AE; Canadian Lrrk2 in Inflammation Team (CLINT); Park DS. Kim KS, et al. Among authors: callaghan sm. Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5164-E5173. doi: 10.1073/pnas.1718946115. Epub 2018 May 14. Proc Natl Acad Sci U S A. 2018. PMID: 29760073 Free PMC article.
43 results