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Low-dose carboplatin modifies the tumor microenvironment to augment CAR T cell efficacy in human prostate cancer models.
Porter LH, Zhu JJ, Lister NL, Harrison SG, Keerthikumar S, Goode DL, Urban RQ, Byrne DJ, Azad A, Vela I, Hofman MS, Neeson PJ, Darcy PK, Trapani JA, Taylor RA, Risbridger GP. Porter LH, et al. Among authors: keerthikumar s. Nat Commun. 2023 Sep 2;14(1):5346. doi: 10.1038/s41467-023-40852-3. Nat Commun. 2023. PMID: 37660083 Free PMC article.
The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology.
Risbridger GP, Clark AK, Porter LH, Toivanen R, Bakshi A, Lister NL, Pook D, Pezaro CJ, Sandhu S, Keerthikumar S, Quezada Urban R, Papargiris M, Kraska J, Madsen HB, Wang H, Richards MG, Niranjan B, O'Dea S, Teng L, Wheelahan W, Li Z, Choo N, Ouyang JF, Thorne H, Devereux L, Hicks RJ, Sengupta S, Harewood L, Iddawala M, Azad AA, Goad J, Grummet J, Kourambas J, Kwan EM, Moon D, Murphy DG, Pedersen J, Clouston D, Norden S, Ryan A, Furic L, Goode DL, Frydenberg M, Lawrence MG, Taylor RA. Risbridger GP, et al. Among authors: keerthikumar s. Nat Commun. 2021 Aug 19;12(1):5049. doi: 10.1038/s41467-021-25175-5. Nat Commun. 2021. PMID: 34413304 Free PMC article.
Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis.
Samuel M, Fonseka P, Sanwlani R, Gangoda L, Chee SH, Keerthikumar S, Spurling A, Chitti SV, Zanker D, Ang CS, Atukorala I, Kang T, Shahi S, Marzan AL, Nedeva C, Vennin C, Lucas MC, Cheng L, Herrmann D, Pathan M, Chisanga D, Warren SC, Zhao K, Abraham N, Anand S, Boukouris S, Adda CG, Jiang L, Shekhar TM, Baschuk N, Hawkins CJ, Johnston AJ, Orian JM, Hoogenraad NJ, Poon IK, Hill AF, Jois M, Timpson P, Parker BS, Mathivanan S. Samuel M, et al. Among authors: keerthikumar s. Nat Commun. 2021 Jun 24;12(1):3950. doi: 10.1038/s41467-021-24273-8. Nat Commun. 2021. PMID: 34168137 Free PMC article.
Mast Cell-Derived SAMD14 Is a Novel Regulator of the Human Prostate Tumor Microenvironment.
Teng LKH, Pereira BA, Keerthikumar S, Huang C, Niranjan B, Lee SN, Richards M, Schittenhelm RB, Furic L, Goode DL, Lawrence MG, Taylor RA, Ellem SJ, Risbridger GP, Lister NL. Teng LKH, et al. Among authors: keerthikumar s. Cancers (Basel). 2021 Mar 11;13(6):1237. doi: 10.3390/cancers13061237. Cancers (Basel). 2021. PMID: 33799802 Free PMC article.
MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer.
Cipponi A, Goode DL, Bedo J, McCabe MJ, Pajic M, Croucher DR, Rajal AG, Junankar SR, Saunders DN, Lobachevsky P, Papenfuss AT, Nessem D, Nobis M, Warren SC, Timpson P, Cowley M, Vargas AC, Qiu MR, Generali DG, Keerthikumar S, Nguyen U, Corcoran NM, Long GV, Blay JY, Thomas DM. Cipponi A, et al. Among authors: keerthikumar s. Science. 2020 Jun 5;368(6495):1127-1131. doi: 10.1126/science.aau8768. Science. 2020. PMID: 32499442
CRISP3 expression drives prostate cancer invasion and progression.
Volpert M, Furic L, Hu J, O'Connor AE, Rebello RJ, Keerthikumar S, Evans J, Merriner DJ, Pedersen J, Risbridger GP, McIntyre P, O'Bryan MK. Volpert M, et al. Among authors: keerthikumar s. Endocr Relat Cancer. 2020 Jul;27(7):415-430. doi: 10.1530/ERC-20-0092. Endocr Relat Cancer. 2020. PMID: 32357309
Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells.
Kalra H, Gangoda L, Fonseka P, Chitti SV, Liem M, Keerthikumar S, Samuel M, Boukouris S, Al Saffar H, Collins C, Adda CG, Ang CS, Mathivanan S. Kalra H, et al. Among authors: keerthikumar s. J Extracell Vesicles. 2019 Nov 15;8(1):1690217. doi: 10.1080/20013078.2019.1690217. eCollection 2019. J Extracell Vesicles. 2019. PMID: 31819794 Free PMC article.
51 results