Transient neonatal estrogen exposure to estrogen-deficient mice (aromatase knockout) reduces prostate weight and induces inflammation in late life.
Bianco JJ, McPherson SJ, Wang H, Prins GS, Risbridger GP.
Bianco JJ, et al. Among authors: risbridger gp.
Am J Pathol. 2006 Jun;168(6):1869-78. doi: 10.2353/ajpath.2006.050623.
Am J Pathol. 2006.
PMID: 16723702
Free PMC article.
We have addressed this question using aromatase-knockout (ArKO) mice that are estrogen-deficient during their lifespan but have elevated androgen levels and develop prostate enlargement and hyperplasia (McPherson SJ, Wang H, Jones ME, Pedersen J, Iismaa TP, Wreford N, Simpson ER, …
We have addressed this question using aromatase-knockout (ArKO) mice that are estrogen-deficient during their lifespan but have elevated and …