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Transfer Learning Reveals Cancer-Associated Fibroblasts Are Associated with Epithelial-Mesenchymal Transition and Inflammation in Cancer Cells in Pancreatic Ductal Adenocarcinoma.
Guinn S, Kinny-Köster B, Tandurella JA, Mitchell JT, Sidiropoulos DN, Loth M, Lyman MR, Pucsek AB, Zabransky DJ, Lee JW, Kartalia E, Ramani M, Seppälä TT, Cherry C, Suri R, Zlomke H, Patel J, He J, Wolfgang CL, Yu J, Zheng L, Ryan DP, Ting DT, Kimmelman A, Gupta A, Danilova L, Elisseeff JH, Wood LD, Stein-O'Brien G, Kagohara LT, Jaffee EM, Burkhart RA, Fertig EJ, Zimmerman JW. Guinn S, et al. Among authors: seppala tt. Cancer Res. 2024 May 2;84(9):1517-1533. doi: 10.1158/0008-5472.CAN-23-1660. Cancer Res. 2024. PMID: 38587552 Free PMC article.
Precision Medicine in Pancreatic Cancer: Patient-Derived Organoid Pharmacotyping Is a Predictive Biomarker of Clinical Treatment Response.
Seppälä TT, Zimmerman JW, Suri R, Zlomke H, Ivey GD, Szabolcs A, Shubert CR, Cameron JL, Burns WR, Lafaro KJ, He J, Wolfgang CL, Zou YS, Zheng L, Tuveson DA, Eshlemann JR, Ryan DP, Kimmelman AC, Hong TS, Ting DT, Jaffee EM, Burkhart RA. Seppälä TT, et al. Clin Cancer Res. 2022 Aug 2;28(15):3296-3307. doi: 10.1158/1078-0432.CCR-21-4165. Clin Cancer Res. 2022. PMID: 35363262 Free PMC article.
Patient-derived Organoid Pharmacotyping is a Clinically Tractable Strategy for Precision Medicine in Pancreatic Cancer.
Seppälä TT, Zimmerman JW, Sereni E, Plenker D, Suri R, Rozich N, Blair A, Thomas DL 2nd, Teinor J, Javed A, Patel H, Cameron JL, Burns WR, He J, Tuveson DA, Jaffee EM, Eshleman J, Szabolcs A, Ryan DP, Ting DT, Wolfgang CL, Burkhart RA. Seppälä TT, et al. Ann Surg. 2020 Sep 1;272(3):427-435. doi: 10.1097/SLA.0000000000004200. Ann Surg. 2020. PMID: 32657929 Free PMC article.
Circulating miRNA Signature Predicts Cancer Incidence in Lynch Syndrome-A Pilot Study.
Sievänen T, Jokela T, Hyvärinen M, Korhonen TM, Pylvänäinen K, Mecklin JP, Karvanen J, Sillanpää E, Seppälä TT, Laakkonen EK. Sievänen T, et al. Among authors: seppala tt. Cancer Prev Res (Phila). 2024 Jun 4;17(6):243-254. doi: 10.1158/1940-6207.CAPR-23-0368. Cancer Prev Res (Phila). 2024. PMID: 38551987 Free PMC article.
Genetic and Epigenetic Characteristics of Inflammatory Bowel Disease-Associated Colorectal Cancer.
Rajamäki K, Taira A, Katainen R, Välimäki N, Kuosmanen A, Plaketti RM, Seppälä TT, Ahtiainen M, Wirta EV, Vartiainen E, Sulo P, Ravantti J, Lehtipuro S, Granberg KJ, Nykter M, Tanskanen T, Ristimäki A, Koskensalo S, Renkonen-Sinisalo L, Lepistö A, Böhm J, Taipale J, Mecklin JP, Aavikko M, Palin K, Aaltonen LA. Rajamäki K, et al. Among authors: seppala tt. Gastroenterology. 2021 Aug;161(2):592-607. doi: 10.1053/j.gastro.2021.04.042. Epub 2021 Apr 27. Gastroenterology. 2021. PMID: 33930428 Free article.
Tumor-independent Detection of Inherited Mismatch Repair Deficiency for the Diagnosis of Lynch Syndrome with High Specificity and Sensitivity.
Kansikas M, Vähätalo L, Kantelinen J, Kasela M, Putula J, Døhlen A, Paloviita P, Kärkkäinen E, Lahti N, Arnez P, Kilpinen S, Alcala-Repo B, Pylvänäinen K, Pöyhönen M, Peltomäki P, Järvinen HJ, Seppälä TT, Renkonen-Sinisalo L, Lepistö A, Mecklin JP, Nyström M. Kansikas M, et al. Among authors: seppala tt. Cancer Res Commun. 2023 Mar 2;3(3):361-370. doi: 10.1158/2767-9764.CRC-22-0384. eCollection 2023 Mar. Cancer Res Commun. 2023. PMID: 36875157 Free PMC article.
Prognostic significance of spatial and density analysis of T lymphocytes in colorectal cancer.
Elomaa H, Ahtiainen M, Väyrynen SA, Ogino S, Nowak JA, Friman M, Helminen O, Wirta EV, Seppälä TT, Böhm J, Mäkinen MJ, Mecklin JP, Kuopio T, Väyrynen JP. Elomaa H, et al. Among authors: seppala tt. Br J Cancer. 2022 Aug;127(3):514-523. doi: 10.1038/s41416-022-01822-6. Epub 2022 Apr 21. Br J Cancer. 2022. PMID: 35449453 Free PMC article.
93 results